생명과학회지 (Journal of Life Science)

  • 제13권6호
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  • Pages.950-957
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  • 2003
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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Needle TENS가 흰쥐 말초신경손상 후 Nerve Growth Factor발현에 미치는 영향

The Effect of Needle TENS to Nerve Growth Factor(NGF) Revelation After Damage of the Peripheral Nerve of a White Rat

  • 배주한 (경북과학대학 작업치료과) ;
  • 이복규 (동의대학교 자연과학대학 분자생물학과) ;
  • 김상수 (대구보건대학 물리치료과)
  • 발행 : 2003.12.01
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초록

본 연구의 목적은 Needle TENS를 이용하여 웅성 흰쥐를 대조군과 실험군으로 나누어 말초신경손상의 좌골신경을 30초 압좌하여 1일, 3일, 5일, 7일 치료 후 NGF의 변화를 본 결과 다음과 같은 결론을 얻었다. 대조군에서는 1일째 면역반응 신경세포의 수가 많이 증가된 것으로 관찰되었으며, 3일, 5일, 및 7일로 시간이 경과할수록 반응하는 신경세포수는 점점 감소하는 경향을 나타냈으나, 신경손상을 받지 않은 정상부분의 반응양성과 유사한 결과를 나타내었다. 그러나 실험군에서는 1일째는 대조군과 실험군간의 별다른 차이를 보이지 않았으나 3일, 5일, 7일 단위로 치료기간이 길어짐에 따라 면역반응 신경세포의 변화는 뚜렷하게 관찰할 수 있었는데, 대조군과 실험군간의 NGF 변화에서 시간이 경과함에 따라 감소되는 결과를 보였고, 대조군보다는 실험군에서 현저하게 감소하는 것으로 나타났으며, 통계적으로도 유의한 결과를 보였다. 이러한 결과로 볼때 Needle TENS를 적용하니 NGF의 감소를 보여 치료를 촉진시켜 치유과정에 영향을 미친다고 할 수 있다.

The purpose of this study is to classify the contrast group and experiment group of a male white rat, and to identify a result of NFG's change that press the sciatic nerves injured peripheral ones for curing 1day, 3days, 5days and 7days. In contrast group, the nerve cells of immune-reaction were increased on 1 day and they were decreased for 3 days, 5 days, 7 days as a normal one. In experiment group, they were increased on 1 day but, decreased for 3 days, 5 days, 7 days more than contrast group. In conclusion, it is certain that the Needle TENS can make a NFG decrease and effect on the therapy.

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