생명과학회지 (Journal of Life Science)

  • 제13권6호
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  • Pages.911-916
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  • 2003
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
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Opuntia ficus-indica가 Glutathione 및 항산화 효소에 미치는 보호효과

Protective effects of Opuntia ficus-indica on Glutathione and Antioxidative Enzyme

  • 발행 : 2003.12.01
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초록

The effects of Opuntia ficus-indica (OF) administration on the biochemical parameters of function in liver tissue and serum of $CCl_4$ treated rats were investigated. Opuntia ficus-indica (200 mg/kg) was administered into rats intraperitoneally for two weeks. $3.3m\ell$ of $CCl_4$$_4$ (50% $CCl_4$ : Olive oil = 1 : 1) was treated to rats on the 14th day and 15th day and they were operated on 15th day. We examined the antioxidative enzymatic activity by measuring the level of AST (Aspartate aminotransferase), ALT (Alanine aminotransferase), GSH (Glutathione reduced form), GSSG (Glutathione oxidezed form), GPx (GSH-peroxidase), SOD (Superoxide dismutase) and CAT (Catalase) in serum and liver tissue of rats. OFC administered group showed 24.8% of inhibitory effect in AST activity compared to $CCl_4$ -treated abnormal group (CTA). ALT level of OF administered group was decreased by 60.7% to the level of CTA. GSH, GSSG and GPx of OFC administered group were significantly higher than those of CTA group. SOD and CAT in OFC administered group were increased by 28.3% and by 16.9% respectively compared to those of CTA group.

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참고문헌

  1. Arch. Biochem. Biophys. v.247 Biologic effects of the superoxide radicals Fridovich,I. https://doi.org/10.1016/0003-9861(86)90526-6
  2. Neuropharmacology v.32 The effects of mescaline and some of its analogs on cholinergic neuromuscular transmission Kahnsah,E.;P.Kopsombut;M.A.Malque;A.Brossi https://doi.org/10.1016/0028-3908(93)90097-M
  3. J. Food Hug. Safty v.13 A study on antiulcer effects of Opuntia dillenii Haw. on stomach ulcer induced by water-immersion stress in rats Lee,H.J.;Y.W.Lee;J.H.Kim
  4. J. Biol. Chem. v.193 Protein Measurement with folin phenol reagent Lowry,O.H.;N.J.Rosenbrough;A.S.Farr;R.J.Randall
  5. J. Mol. Biol. v.225 X-ray structure refinement and comparison of three forms of mitochondrial asparte aminotransferase McPhalen,C.A.;M.G.Vincent;J.N.Jansonius https://doi.org/10.1016/0022-2836(92)90935-D
  6. Cheju National University, Graduate School. MS thesis Effects of Opuntia ficus-indica fruit on the passive auoidance and anti-oxidation in the senescince-accelerated mouse Paik,S.
  7. Arch. Pharm. Res. v.21 Studies on the pharmacological action of cactus : identification of its anti-inflammatory effect Park,E.H.;J.H.Kahng;E.A.Paek https://doi.org/10.1007/BF03216749
  8. Pharmacol. Review v.19 Carbon tetrachloride hepatotoxicity. Recknagel,R.O.
  9. Nature v.362 Mutations with familial amyotrophic lateral sclerosis Rosen,D.R.(et al.) https://doi.org/10.1038/362059a0
  10. Kor. J. Vet. Pathol. v.2 Effects of Opuntia ficus-indica extract on the activation of immune cells with special reference to autoimmune disease models Shin,T.;S.Kim;S.Lee
  11. Opuntia ficus-indica ethanol extract ameliorates streptozotocin-induced hyperglycemia in rats Shin,T.;S.Kim;C.Moon;M.Wie;B.Hyun
  12. Free Radical Biology & Medicine v.27 no.11;12 LOW-DOSE γ-RAY IRRADIATION REDUCES OXIDATIVE DAMAGE INDUCED BY CCl4 IN MOUSE LIVER Takaharu Nomura;Kiyonori Yamaoka https://doi.org/10.1016/S0891-5849(99)00180-X
  13. Nature v.306 Structure and mechanism of Cu, Zn, superoxide dismutase Tainer,J.A.;E.D.Getzoff;J.S.Richardson;D.C.Richardson https://doi.org/10.1038/306274a0
  14. The Chemical Basis of Radiation of biology Von, Sonntag