Collagen Formation and Adhesion of Human Gingival Fibroblasts on the IBAD Ca-P Coating on Ti

  • B. H. Zhao (Department of Prosthodontics, School of Stomatology, Peking University) ;
  • F. Z. Cui (Department of Materials Science & Engineering, Tsinghua University) ;
  • Lee, I-S. (Atomic-scale Surface Science Research Center, Yonsei University) ;
  • W. Bai (Department of Prosthodontics, School of Stomatology, Peking University) ;
  • H. L. Feng (Department of Prosthodontics, School of Stomatology, Peking University)
  • 발행 : 2003.10.01

초록

Coatings of hydroxyapatite (HA) and tricalcium phosphate/HA (TCP/HA) on titanium were fabricated by ion beam assisted deposition (IBAD). Significant effect of the Ca-P coatings on human Gingival Fibroblasts (HGFs) attachment and formation of type I collagen were found by using immunofluorescence microscope. TCP/HA and HA coatings exerted more HGFs attachment and collagen I formation. Comparing with HA coating, TCP/HA coating exhibited better responses during the late period of the tests. This investigation indicated that this surface modification method may enhance the biological seal at the cervical level of the titanium dental implants.

키워드

참고문헌

  1. W. Vrouwenvwelder, C. Groot, and K. de Groot, J. Biomed. Mater. Res. 27, 465 (1993) https://doi.org/10.1002/jbm.820270407
  2. K. de Groot, R. Geesink, C. P. A. T. Klein, and P. Srerkian, J. Biomed. Mater. Res. 21, 1375 (1987) https://doi.org/10.1002/jbm.820211203
  3. J. Chen, J.G.C. Wolke, and K. de Groot, Bio-materials. 15, 396 (1994)
  4. K. A. Gross, C. C. Berndt, J. Mater. Sci. 5, 219 (1994)
  5. F. Z. Cui, Z. S. Luo, and Q. L. Feng, J. Mater. Sci-Mater M, 8, 403 (1997) https://doi.org/10.1023/A:1018597320022
  6. N. Pender and C. A. G. McCulloch, J. Cell Sci. 100, 187 (1991)
  7. I. S. Lee, C. N. Whang, G. H. Lee, F. Z. Cui, and A. Ito, Nuclear Instruments and Methods in Physics Research B 206, 522 (2003) https://doi.org/10.1016/S0168-583X(03)00773-0
  8. I. S. Lee, D. H. Kim, H. E. Kim, Y. C. Jung, and C. H. Han, Biomaterials 23, 609 (2002) https://doi.org/10.1016/S0142-9612(01)00147-8
  9. V. Grill, M. A. Sandrucci, M. Basa, R. Di-Lenarda, E. Dorigo, A. M. Martelli, R. Bareggi, and P. Narducci, Boll. Soc. Ital. Biol. Sper. 72, 87 (1996)
  10. T. Matsuura, R. Hosokawa, K. Okamoto, T. Kimoto, and Y. Akagawa. Biomaterials 21, 1121 (2000) https://doi.org/10.1016/S0142-9612(99)00264-1
  11. K. L. Kilpadi, P. L. Chang, and S. L. Bellis, J Biomed. Mter. Res. 57, 258 (2001) https://doi.org/10.1002/1097-4636(200111)57:2<258::AID-JBM1166>3.0.CO;2-R