생명과학회지 (Journal of Life Science)

  • 제13권5호
  • /
  • Pages.569-575
  • /
  • 2003
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
DOI QR코드

DOI QR Code

초임계 CO2를 이용한 Saw palmitto로부터 전립선 비대 유효 성분의 추출 조건

Process conditions of valuable compound for benign prostatic hyperplasia(BPH) from saw palmitto by supercritical CO2

  • 발행 : 2003.10.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

초임계 이산화탄소를 이용하여 saw palmitto로부터 전립선 비대증 치료를 위한 유효성분을 효율적으로 추출하기 위하여 초임계 유체의 압력(22, 30 Mpa), 온도 $(35^{\circ}C,\; 60^<\circ}C)$, 및 보조용매의 농도, 및 추출시간에 다른 효율을 조사하였다. 보조 용매로는 메탄올보다는 에탄올이 효과적이었고. 보조용매의 농도가 증가할수록 유효성의 추출 효율은 증가하였고 15% 에탄올 농도에서 효율이 가장 높았다. 15%에탄올 농도에서 초임계유체의 최적 추출조건은 압력은 30 Mpa, 온도는$60^<\circ}C$이였고, 추출시간에 따른 추출효율은 추출시간이 증가할수록 완만하게 증가하는 경향을 나타내었다. 초임계 이산화탄소의 추출조건으로 saw palmitto로부터 전립선 비대 치료를 위한 유효물질을 추출할 수 있다.

Supercritical $CO_2$ extraction was applied to extraction of the valuable compound for benign prostatic hyperplasia from saw palmitto. Three levels of parameters, temperature $(35^{\circ}C,\; 60^<\circ}C)$, pressure 22∼30 Mpa and ethanol modified solvent concentration, were used as the independent variables of central composite to rotate the design. The extracting pressure and temperature interaction was significantly affected the extraction of valuable compounds. The ethanol was an efficient modifier to extract valuable compound by supercritical carbon dioxide. The optimal processing conditions were extracting pressure, 30 Mpa, extracting temperature, $60^<\circ}C$, ethanol modifier, 15% for extracts of the valuable compounds from saw palmitto. In conclusion, it was found that supercritical $CO_2$ extraction can successfully be applied to extract high quality extracts from saw palmitto.

키워드

참고문헌

  1. supercritical Fluids fundamentals for application Reaction in Supercritical Fluids Cliford,A.A.;E.Kiran(ed.);J.M.H.Levelt Sengers(ed.)
  2. Drug Benefi Trends. v.7 Cost-effective management of Benign Prostatic Hyper-plasia Cooper,J.W.;R.W.Piepho
  3. Terpenoids and flavonoids Plant pigments, flavors and textures : The chemistry and Biochemistry of Selected Compounds Eskin,N.A.M.
  4. Infect. Urol. v.10 Medical theaphy for Benign Prostatic Hyperplasia Keetch,D.W.
  5. N Engl. J. Med. v.335 The efficacy of etrazosin, finasteride, or both in BPH Lepor,H. https://doi.org/10.1056/NEJM199608223350801
  6. J. Am. Oil Chem. Soc. v.68 Process conditions for separating fatty acid esters by suprcritical CO₂ Liang,J.H.;A.I.Yeh https://doi.org/10.1007/BF02662298
  7. Anal. Chem. v.38 Rapid preparation of fatty acid esters from lipid for gas chromatographic analysis Metacalf,L.D.;A.A.Schmitz;J.R.Palka https://doi.org/10.1021/ac60235a044
  8. Drug Benefit Trends. v.9 New clinical trial of medical therapy for benign Prostatic Hyperplasia Nixon,P.
  9. Anai. Chem v.53 Capillary Supercritical Fluid Chromatography Novotny,M.;S.R.Springton;P.A.Peaden;J.C.Fjelsted;M.L.Lee https://doi.org/10.1021/ac00226a731
  10. J. Liq. Chromatogr. v.5 Supercritical Fluid Chromatography: methods and principles Peaden,P.A.;M.L.Lee
  11. Engineering and Food, Avanced Processes v.3 Supecritical fluid Processing of milk fat Rizvi,S.S.H.;S.Lim;H.Nikoopour;M.Sin;Z.Yu;Spiess,W.E.L.(ed.);Schubert,H.(ed.)
  12. Supercritical fluid processing of foods and biomaterials(Ist ed.) Rizvi,S.S.H.
  13. Fractionation by packed column SFC and SFE Saito,M;Y.Yamauchi;T.Okuyama
  14. Anal. Chem. v.30 Automatic recording apparatus for use in the chromatography of amino acids Spackmann,D.H.;W.H.Stein;S.Moore https://doi.org/10.1021/ac60139a006
  15. Gases for Extraction and Refining Stahl,E.;K.W.Quirin;D.Geraed;A.Dense
  16. Supercritical Fluid Extraction Taylor,L.T.