Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Effect of Calcium Sulfate and Sodium Hyaluronate on Early Bone Consolidation in Distraction Osteogenesis of the Canine Mandible

개의 하악골에서 신생골 조기 골경화에 Calcium Sulfate와 Sodium Hyaluronate가 미치는 영향

  • 이주명 (제주대학교 수의학과) ;
  • 조병채 (경북대학교 의과대학 성형외과학교실)
  • Published : 2003.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this experiment was to study the calcium sulfate on early bone consolidation in distraction osteogenesis in the canine mandible. Twelve dogs were used and divided into control group (group A, 4 heads), sodium hyaluronate injection group (group B, 4 heads), mixture of calcium sulfate and sodium hyaluronate injection group (group C, 4 heads). Each group were subdivided into 3 weeks testing group (totally 6 heads) and 5 weeks testing group (totally 6 heads). Mandibular distraction was started at the 5th day after the mandibular osteotomy and continued for 10 days by 1 mm a day. After the distraction on the 10th day of mandibular distraction, 0.5 m1 saline in group A, 0.5 m1 sodium hyaluronate in group B, and 0.5 ml mixture of calcium sulfate and sodium hyaluronate in group C were each injected in mandibular distraction lesion. And X-ray examination, bone mineral density, and histopathological findings were examined. The radiological findings were the most radiopaque in group C, and the most radiolucent in group A in both 3 and 5 week testing group. The level of bone mineral density was also the highest in group C, and the lowest in group C in both 3 and 5 week testing group. The histopathological findings of new bone formation were the most remarkable in group C in both 3 and 5 week testing group. New bone formation of group A was not present in both 3 and 5 week testing group. In conclusion, calcium sulfate is a kind of material that can stimulate early bone formation and can shorten the duration of bone consolidation. And it can be effective in clinical usage.

Keywords

References

  1. Clin Orthop v.238 The tension-stress effect on the genesis and growth of tissues. Part Ⅰ: the influence of stability of fixation and soft tissue preservation Ilizarov,G.A.
  2. Science v.150 Bone formation by autoinduction Urist,M.R. https://doi.org/10.1126/science.150.3698.893
  3. J. Bone. Join Surg v.73 no.Am Transforming growth factor-beta and remodeling of bone Centrella,M.;McCarthy,T.L.;Canalis,E. https://doi.org/10.2106/00004623-199173090-00022
  4. Oral Surg Oral Med Oral Pathol Oral Radio Endod v.84 Bone regeneration with a calcium sulfate barrier Pecora,G.;Andreana,S.;Margarone,J.E.;Covani,U.;Sottosanti,J.S. https://doi.org/10.1016/S1079-2104(97)90043-3
  5. Biomaterials v.15 Stimulatory effect on bone formation exerted by a modified chitosan Muzzarelli,R.A.;Mattioli-Belmonte,M.;Tiets,C.;Biagini,R.;Feioli,G.;Brunelli,M.A.;Fini,M.;Giardino,R.;Ilari,P.;Biagini,G. https://doi.org/10.1016/0142-9612(94)90093-0
  6. J. Periodontol v.67 Osteogenesis enhanced by chitosan(poly-β-acetyl glucos-aminoglycan) in vitro Klokkevold,P.R.;Vandemark,L.;Kenney,E.B.;Bernard,G.W. https://doi.org/10.1902/jop.1996.67.11.1170
  7. J. Bone. Join. Surg. v.72-B The timing of distraction of an osteotomy White,S.H.;Kenwright,J. https://doi.org/10.1302/0301-620X.72B3.2341426
  8. Orthop Clin North Amer v.22 The importance of delay in distraction of osteotomies White,S.H.;Kenwright,J.
  9. J. Craniomaxillofac Surg v.26 Seven years clinical experience with mandibular distraction in children Carls,F.R.;Sailer,H.F. https://doi.org/10.1016/S1010-5182(98)80015-2
  10. Arch Otolaryngol v.107 Plaster of Paris as an alloplastic implant in the frontal sinus Beeson,W. https://doi.org/10.1001/archotol.1981.00790470012004
  11. Am J. Surg v.97 no.3 The use of plater of Paris to fill large defects in bone Pelter,L.F. https://doi.org/10.1016/0002-9610(59)90305-8