Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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The Wound Contractive Effects of Chitosan, Aloe Vera, Fucidin Natrium and Premycin Ointment on Skin Defect Wound in Dogs

개의 피부 결손창에서 창상수축에 대한 Chitosan, Aloevera, Fucidin Natrium 및 Premycin Ointment의 효과

  • Published : 2003.09.01
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Abstract

This study was carried out to investigate the effects of the wound contraction of chitosan, aloe vera, fucidin natrium, and premycin ointment on defected wound from full-thickness skin defects(1 cm $\times$ 1 cm). Twelve dogs were designed in 5 different positions on the dorsal thoracolumbar. We examined the effects of wound contraction every four other day 16 for days. Percentage of wound contraction based on epitherial overall area of defected wound which calculated by image analyzer and computer. Four to 8 days after wound contraction in wound defected dogs, the epithelial overall rate were the most high presented by 48.1 % in the chitosan group and were the lowest by 26.8% in the premycin group. In 16 days, chitosan group were the most heigh presented by 94.4% and premycin group were the lowest by 76.5% compare to saline group of 85.9%. Thus, we conclude that the chitosan is a possible role for improvement of wound contraction by wound defected dogs.

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References

  1. Canine Surgery(2nd ed.) Basic procedures and preoperative consideration Archibald,J.;Blakely,C.L.;Archibald,J.(ed.)
  2. Clin. Symp. v.29 Wound healing Bryant,W.M.
  3. Ann. Surg. v.167 The effects of cortisone and vitamine A on wound healing Ehrlich,H.P.;Hunt,T.K. https://doi.org/10.1097/00000658-196803000-00004
  4. J. Exp. Med. v.135 Granulation tissue as a contractile organ: A study of structure and function Gabbiani,G.;Hirschel,B.J.;Ryan,G.B.(et al.) https://doi.org/10.1084/jem.135.4.719
  5. Am. J. Pathol. v.66 Dupuytren's contracture: Fibroblast contraction Gabbiani,G.;Majno,G.
  6. Experientia v.27 Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction Gabbiani,G.;Ryan,G.B.;Majno,G. https://doi.org/10.1007/BF02147594
  7. Clin Dermatol v.17 Traditional Approaches to Wound Healing Gerard C. Bodeker;Terenece J. Ryan;Chi-Keong Ong
  8. Biomaterials v.22 The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro Graeme I. Howling;Peter W. Dettmar;Paul A. Goddard;Frank C. Hampson;Michael Dornish;Edward J. Wood https://doi.org/10.1016/S0142-9612(01)00042-4
  9. J. Ethnopharmacol v.55 Antiinflammatory activity of extracts from Aloe vera gel Guillermo Avila;David Segura;Bruno Escalante(et al.) https://doi.org/10.1016/S0378-8741(96)01476-6
  10. Adv Drug Deliv Rev. v.52 Topical formulations and wound healing applications of chitosan Hiroshi,U.;Takashi,M.;Toru,F. https://doi.org/10.1016/S0169-409X(01)00189-2
  11. Biomaterials v.20 Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs Hiroshi,U.;Haruo,Y.;Naoki,K.;Mitsunobu,M.;Masahiro,O.;Tsuyushi,K.;Toru,F. https://doi.org/10.1016/S0142-9612(99)00046-0
  12. Int. J. Antimicrob. Agents. v.12 Fusidic acid pharmarcology, pharmacokinetics and pharmacodynamics John Turnidge https://doi.org/10.1016/S0924-8579(98)00071-5
  13. J. Am. Anim. Hosp. Assoc. v.13 The processes in wound healing Johnston,D.E.
  14. Am. Coll. Vet. Surg. v.3 Wound healing arch Johnston,D.E.
  15. Int J. Antimicrob Agents. v.12 Fusidic acid non-antibacterial activity Keryn,C. https://doi.org/10.1016/S0924-8579(98)00076-4
  16. Immunophamacology v.35 Activation of a mouse macrophage cell line by acemnnan: The major carbohydrtate fraction from Aloe vera gel Linna Zhang;Ian R. Tizard https://doi.org/10.1016/S0162-3109(96)00135-X
  17. Textbook of Surgery(11th ed.) Wound healing: Biologic and clinical features Madden,J.W.;Sabiston,D.C.(ed.);Davis-Christopher(ed.)
  18. Reactive & functional Polymer v.46 A review of chitin and chitosan applications Majeti N.V. Ravi Kumar https://doi.org/10.1016/S1381-5148(00)00038-9
  19. J. Dermatol Surg Oncol v.15 Role of Topical Agents in the Healing of Full-Thickness Wound Melissa,A.W.;Ronald,G.W. https://doi.org/10.1111/j.1524-4725.1989.tb03232.x
  20. J. Ethnopharmacol v.59 Influence of aloe vera on the healing of dermal wounds in diabetic rats P.Chithra;G.B.Sajithlal;Gowri Chandrakasan https://doi.org/10.1016/S0378-8741(97)00124-4
  21. J. Ethnopharmacol v.59 Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats P.Chithra;G.B.Sajithlal;Gowri Chandrakasan https://doi.org/10.1016/S0378-8741(97)00112-8
  22. Reconstructive Plastic Surgery: Principles and Procedures in Correction, Reconstruction, Transplantation(2nd ed.) v.1 Repair and regeneration Peacock,E.E.;Converse,J.M.(ed.)
  23. Wound Repair(2nd ed.) Peacock,E.E.;Van Winkle,W.
  24. J. Pharm Pharm Sci v.3 Mechanical, bioadhesive strength and biological evaluations of chitosan films for wound Peh,K.;Khan,T.;Ch'ng,H.
  25. Int. J. Antimicrob Agents v.12 Fusidic acid in vitro activity Peter,C.;John,T. https://doi.org/10.1016/S0924-8579(98)00073-9
  26. Prog. Surg. v.2 Some aspects of the repair process in mammals Russell,P.S.;Billingham,R.E.
  27. J. Am. Podiatr Med. Assoc. v.84 no.2 Anti-inflammatory and Wound healing Activity of a Growth Substance in Aloe Vera Robert H. Davis;Glenn M. Hartman(et al.) https://doi.org/10.7547/87507315-84-2-77
  28. Int. J. Antimicrob Agents v.12 Fusidic acid in skin and soft tissue infections Spelman,D. https://doi.org/10.1016/S0924-8579(98)00074-0
  29. Surgery of traumatized skin Steven F. Swaim
  30. Biomaterials v.18 Effects of chitin and its derivatives on the proliferation and cytokine production of fibroblasts in vitro Takashi,M.;Masahiro,O.;Mitsunobu,M.;Keisuke,U.;Seiichi,T.;Yoshiharu,O.;Sabro,M.;Toru,F. https://doi.org/10.1016/S0142-9612(97)00017-3
  31. Int. J. Pharm. v.182 Effects of chitosan on epithelial permeability and structure Valerie Dodane;M. Amin Khan;June R. Merwin https://doi.org/10.1016/S0378-5173(99)00030-7
  32. J. Vet. Med. Sci. v.57 no.5 Evaluation of Chitin and Chitosan on open Wound Healing in Dogs Yoshiharu,O.;Kenji,S.;Saburo,M.;Akira,M.;Shin-ichiro,T.;Yoshihiro,S. https://doi.org/10.1292/jvms.57.851
  33. J. Vet. Med. Sci. v.57 no.4 Effects of Chitosan on Experimental Abscess with Stapylococcus aureus in Dogs Yoshiharu,O.;Tamotsu,T.;Saburo,M.;Akira,M.;Norichika,H.K.;Shin-ichiro,T.;Yoshihiro,S. https://doi.org/10.1292/jvms.57.765