Macromolecular Research

  • 제11권5호
  • /
  • Pages.317-321
  • /
  • 2003
  • /
  • 1598-5032(pISSN)
  • /
  • 2092-7673(eISSN)
한국고분자학회 (The Polymer Society of Korea)
권호 표지

Preparation and Antitumor Activities of Poly(polyethylene glycol methacrylate-co-methacryloyloxymethyl-5-fluorouracil) Prodrug

  • Cho, Suk-Hyung (Division of High-Tech Material and Electronics, Hyejeon College) ;
  • Kim, Kong-Soo (Division of Chemical Engineering, Chungbuk National University)
  • 발행 : 2003.10.01
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초록

In order to prepare a prodrug, poly(polyethylene glycol methacrylate-co-methacryloyloxymethyl-5-fluorouracil) (poly(PEGM-co-MAOFU)) prodrug particles were prepared by precipitation polymerization of MAOFU and PEGM in polyacrylic acid solution. The size of prodrug particles were 0.2-0.35 ${\mu}{\textrm}{m}$. The antitumor activity of prodrugs against sarcoma-l80 tumor cell in mice was demonstrated and the polymer particles themselves showed low toxicity and good biocompatibility when they were administrated into mice.

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참고문헌

  1. Chem. Pharm. Bull. v.35 S.Ahmad;S.Ozaki;T.Nagase;M.Ligo;A.Hoshi https://doi.org/10.1248/cpb.35.4137
  2. Jpn. J. Cancer Res. v.72 M.Hasida;A.Sato;T.Kojima;S.Muranishi;H.Sezaki;N.Tanigawa;K.Satomura;Y.Hikasan
  3. Chem. Pharm. Bull. v.35 H.Onishi;T.Gawaguchi;T.Nagai https://doi.org/10.1248/cpb.35.3370
  4. J. Marcromol. Sci. Chem. v.A24 T.Ouchi;H.Yuyama;Oogl
  5. Polym. J. v.22 T.Yang;R.Zhno https://doi.org/10.1295/polymj.22.572
  6. J. Bioact. Compat. Polym. v.2 M.Akashi;N.Miyauchi;N.Morita;T.Minota https://doi.org/10.1177/088391158700200304
  7. Chem. Pharm. Bull. v.34 S.Ozaki;Y.Watanabe;T.Hoshico;T.Nagase;T.Ogasawara;H.Furukawa;A.Uemura;K.Ishikawa;M.Mori;M.Iigo;R.Tokuzen https://doi.org/10.1248/cpb.34.150
  8. Polymer(Korea) v.18 S.H.Cho;K.S.Kim;J.K.Kang;B.H.Cho.
  9. Polym. J. v.22 F.Yong;R.Zhuo https://doi.org/10.1295/polymj.22.572
  10. Cancer Res. v.47 Y.Tusukuda;K.Okawa;N.Hibi
  11. Polym. J. v.19 S.Ozaki;J.Ohnishi;Y.Watanabe;T.Nohda;T.Nagase;T.Akiyama.N.Uehara;A.Hoshi
  12. J. Polym. Sci., Polym. Chem. Ed. v.18 Y.Kita;Y.Imaki;K.Takemoto
  13. J. Immunol. Methods v.101 N.Endo;N.Umemoro;Y.Koto;T.Hara
  14. Polym. J. v.22 S.Ozaki;J.Ohnishi;T.Akiyama;T.Nagase;N.Uehara;A.Hoshi https://doi.org/10.1295/polymj.22.689
  15. Cancer Res. v.50 M.Yokoyama;M.Miyauchi;N.Yamada;T.Okano;Y.Sakurai;K.Kataoka
  16. Macromol. Res. S.H.Cho;K.S.Kim
  17. J. Pharm. Sci. v.81 T.Gawaguchi;A.Tsugane;K.Higashide https://doi.org/10.1002/jps.2600810606
  18. Nature v.194 A.J.Sbarra;W.Shirley;W.A.Bardowil https://doi.org/10.1038/194255a0
  19. Adv. Polym. Sci. v.57 R.Duncan;J.Kopecek https://doi.org/10.1007/3-540-12796-8_10