References
- FEMS Immunol. Med. Microbiol. v.36 Analysis of the rdxA gene in high-level metronidazole-resistant clinical isolates confirms a limited use of rdxA mutations as a marker for prediction of metronidazole resistance in Helicobacter pylori Bereswill,S.;C.Krainick;F.Stahler;L.Herrmann;M.Kist https://doi.org/10.1016/S0928-8244(03)00031-2
- J. Antimicrob. Chemother. v.29 Proposed mechanism for metronidazole resistance in Helicobacter pylori Cederbrant,G.;G.Kahlmeter;A.Ljungh https://doi.org/10.1093/jac/29.2.115
- Biochem. Biophys. Res. Commun. v.236 Isolation of a genetic locus associated with metronidazole resistance in Helicobacter pylori Chang,K.C.;S.W.Ho;J.C.Yang;J.T.Wang https://doi.org/10.1006/bbrc.1997.7050
- Antimicrob. Agents Chemother. v.43 Insertion of Mini-IS605 and deletion of adjacent sequences in the nitroreductase (rdxA) gene cause metronidazole resistance in Helicobacter pylori NCTC11637 Debets-Ossenkopp,Y.J.;R.G.Pot;D.J.van Westerloo;A.Goodwin;C.M.Vandenbroucke-Grauls;D.E.Berg;P.S.Hoffman;J.G.Kusters
- Mol. Microbiol. v.28 Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase Goodwin,A.;D.Kersulyte;G.Sisson;S.J.Zanten;D.E.Berg;P.S.Hoffman https://doi.org/10.1046/j.1365-2958.1998.00806.x
- Antimicrob. Agents Chemother. v.34 In vitro selection of resistant Helicobacter pylori Haas,C.E.;D.E.Nix;J.J.Schentag https://doi.org/10.1128/AAC.34.9.1637
- Eur. J. Gastroenterol. Hepatol. v.12 Isolation of a single strain of Helicobacter pylori from antrum and body Hua,J.;K.L.Ling;H.S.Ng;B.Ho https://doi.org/10.1097/00042737-200012100-00010
- Helicobacter v.4 Predominance of a single strain of Helicobacter pylori in gastric antrum Hua,J.;H.C.Ng;K.G.Yeoh;B.Ho https://doi.org/10.1046/j.1523-5378.1999.09043.x
- Microbios v.94 Characterization of clinical isolates of Helicobacter pylori in Singapore Hua,J.;H.C.Ng;K.G.Yeoh;K.Y.Ho;B.Ho
- J. Antimicrob. Chemother. v.43 The role of the rdxA gene in the evolution of metronidazole resistance in Helicobacter pylori Jenks,P.J.;R.L.Ferrero;A.Labigne https://doi.org/10.1093/jac/43.6.753
- Antimicrob. Agents Chemother. v.43 Exposure to metronidazole in vivo readily induced resistance in Helicobacter pylori and reduces the efficacy of eradication therapy in mice Jenks,P.J.;A.Libigne;R.L.Ferrero https://doi.org/10.1093/jac/43.6.777
- J. Bacteriol. v.183 Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole Jeong,J.Y.;A.K.Mukhopadhyay;J.K.Akada;D.Dailidiene;P.S.Hoffman;D.E.Berg https://doi.org/10.1128/JB.183.17.5155-5162.2001
- J. Antimicrob. Agents v.48 Recommendations for the susceptibility tests on fastidious organisms and those requiring special handling King,A. https://doi.org/10.1093/jac/48.suppl_1.77
- Antimicrob. Agents Chemother. v.44 Analysis of rdxA and involvement of additional genes encoding NAD(P)H flavin oxidoreductase (FrxA) and ferredoxin-like protein(FrxB) in metronidazole resistance of Helicabacter pylori Kwon,D.H.;F.A.El-Zaatari;M.Kato;M.S.Osato;R.Reddy;Y.Yamaoka;D.Y.Graham https://doi.org/10.1128/AAC.44.8.2133-2142.2000
- Int. J. Antimicrob. Agents. v.15 Quantiative RT-PCR analysis of multiple genes encoding putative metronidazole nitroreductases from Helicobacter pylori Kwon,D.H.;M.S.Osato;D.Y.Graham;F.A.El-Zaatari https://doi.org/10.1016/S0924-8579(00)00122-9
- J. Antimicrob. Agents v.46 Frameshift mutations in rdxA and metronidazole resistance in North American Helicobacter pylori isolates Kwon,D.H.;J.A.Pena;M.S.Osato;J.G.Fox;D.Y.Graham;J.Versalovic https://doi.org/10.1093/jac/46.5.793
- Res. Microbiol. v.154 Characterization of the genes rdxA and frxA involved in metronidazole resistance in Helicobacter pylori Marais,A.;C.Bilardi;F.Cantet;G.L.Mendz;F.Megraud https://doi.org/10.1016/S0923-2508(03)00030-5
- Eur. J. Gastroenterol. Hepatol. v.11 no.Sup.2 Resistance of Helicobacter pylori to antibiotics: the main limitation of current proton-pump inhibitor triple therapy Megraud,F. https://doi.org/10.1097/00042737-199908002-00006
- J. Gastroenterol. Hepatol. v.11 Metronidazole resistance: A predictor of failure of Helicobacter pylori eradication by triple therapy Midolo,P.D.;J.R.Lambert;J.Turnidge https://doi.org/10.1111/j.1440-1746.1996.tb00078.x
- J. Clin. Microbiol. v.37 DNA fingerprinting of single colonies of Helicobacter pylori from gastric cancer patients suggests infection with a single predominant strain Miehlk,S.;R.Thomas;O.Guiterrez;D.Y.Graham;M.F.Go
- Aliment. Pharmacol. Ther. v.13 The effect of antibiotic resistance on the outcome of three 1-week triple therapies against Helicobacter pylori Pilotto,A.;G.Leandro;M.Franceschi;M.Rassu;L.Bozzola;F.Furlan;F.di Mario;G.Valerio https://doi.org/10.1046/j.1365-2036.1999.00508.x
- J. Bacteriol. v.182 Metronidazole activation is mutagenic and causes DNA fragmentation in Helicobacter pylori and in Escherichia coli containing a cloned H. pylori rdxA+(nitroreductase) gene Sisson,G.;J.Y.Jeong;A.Goodwin;L.Bryden;N.Rossler;S.Lim-Morrison;A.Raudonikiene;D.E.Berg https://doi.org/10.1128/JB.182.18.5091-5096.2000
- J. Antimicrob. Chemother. v.36 The influence of microaerophilia and anaerobiosis on metronidazole uptake in Helicobacter pylori Smith,M.A.;D.I.Edwards https://doi.org/10.1093/jac/36.3.453
- J. Antimicrob. Chemother. v.39 Oxygen scavenging, NADH oxidase and metronidazole in Helicobacter pylori Smith,M.A.;D.I.Edwards https://doi.org/10.1093/jac/39.3.347
- Antimicrob. Agents Chemother. v.44 Mechanism of metronidazole resistance in Helicobacter pylori: Comparison of the rdxA gene sequences in 30 strains Solca,N.M.;M.V.Bernasconi;J.C.Piffaretti https://doi.org/10.1128/AAC.44.8.2207-2210.2000
- Helicobacter v.1 Identification of a 23S rRNA gene mutation in clarithromycin-resistant Helicobacter pylori Stone,G.G.;D.Shortridge;R.K.Flamm;J.Versalovic;J.Beyer;K.Idler;L.Zulawinski;S.K.Tanaka https://doi.org/10.1111/j.1523-5378.1996.tb00043.x
- Antimicrob. Agents Chemother. v.44 Frequent association between alteration of the rdxA gene and metronidazole resistance in French and North African isolates of Helicobacter pylori Tankovic,J.;D.Lamarque;J.C.Delchier;C.J.Soussy;A.Labigne;P.J.Jenks https://doi.org/10.1128/AAC.44.3.608-613.2000
- Nature v.388 The complete genome sequence of the gastric pathogen Helicobacter pylori Tomb,J.F.;O.White;A.R.Kerlavage;R.A.Clayton;G.G.Sutton;R.D.Fleischmann;K.A.Ketchum;H.P.Klenk;S.Gill;B.A.Dougherty;K.Nelson;J.Quackenbush;L.Zhou;E.F.Kirkness;S.Peterson;B.Loftus;D.Richardson;R.Dodson;H.G.Khalak;A.Glodek;K.McKenney;L.M.Fitzegerald;N.Lee;M.D.Adams;J.C.Venter(et al.) https://doi.org/10.1038/41483
- Antimicrob. Agents Chemother. v.38 In vitro studies on stability and development of metronidazole resistance in Helicobacter pylori van Zwet,A.A.;J.C.Thijs;S.de Vries;W.Schievink;J.Schiphuis;J.A.Snijder https://doi.org/10.1128/AAC.38.2.360
- Antimicrob. Agents Chemother. v.40 Mutations in 23SrRNA are associated with clarithromycin resistance in Helicobacter pylori Versalovic,J.;D.Shortridge;K.Kibler;M.V.Griffy;J.Beyer;R.K.Flamm;S.K.Tanaka;D.Y.Graham;M.F.Go