Biomedical Science Letters (대한의생명과학회지)
- Volume 9 Issue 2
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- Pages.59-65
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- 2003
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
SB202190- and SB203580-Sensitive p38 Mitogen-Activated Protein Kinase Positively Regulates Heat Shock- and Amino Acid Analog-Induced Heat Shock Protein Expression
- Kim, Sun-Hee (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
- Han, Song-Iy (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
- Oh, Su-Young (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
- Seo, Myoung-Suk (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
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Park, Hye-Gyeong
(Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
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Kang, Ho-Sung
(Department of Molecular Biology, College of Natural Sciences, Pusan National University)
- Published : 2003.06.01
Abstract
When cells are exposed to proteotoxic stresses such as heat shock, amino acid analogs, and heavy metals, they increase the synthesis of the heat shock proteins (HSPs) by activating the heat shock transcription factor 1 (HSF1), whose activity is controlled via multiple steps including homotrimerization, nuclear translocation, DNA binding, and hyperphosphorylation. Under unstressed conditions, the HSF1 activity is repressed through its constitutive phosphorylation by glycogen synthase kinase 3