Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Association Study between Vitamin D Receptor Gene Polymorphism and Adult Periodontitis in Korea

  • Kang, Byung-Yong (Research Institute for Life Science and Sahmyook University) ;
  • Ha, Nam-Joo (Department of Pharmacy, Sahmyook University)
  • Published : 2003.06.01
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Abstract

Adult periodontitis is a chronic inflammatory disease whose etiology is not well defined. Recent studies have shown that vitamin D receptor gene has been a candidate for the susceptibility of adult periodontitis. The purpose of this study is to investigate the frequency of Taq I restriction fragment length polymorphism (RFLP) in the vitamin D receptor gene in nan periodontically healthy controls and 28 adult periodontitis patients. Taq I RFLP in the vitamin D receptor gene was detected by PCR amplification, followed by restriction enzyme digestion and 2％ agarose gel electrophoresis. There was no significant difference in the distribution of Taq I RFLP between healthy controls and adult periodontitis group (P > 0.05). Thus, Taq I RFLP in the vitamin D receptor gene may not confer the susceptibility to adult periodontitis in Korean population. However, t allele distributions of this RFLP showed various frequencies among ethnic groups studied. Further studies in other ethnic groups will be required.

Keywords

References

  1. Bae JS, Kang BY, Kim KT, Shin JH, and Lee CC (2001) Genetic variation in six candidate genes for insulin resistance in Korean essential hypertensives. Korean J Biol Sci 5: 341-346 https://doi.org/10.1080/12265071.2001.9647625
  2. Bellamy R, Ruwende C, Corrah T, McAdam KPWJ, Thursz M, Whittle HC, and Hill AVS (1999) Tuberculosis and chronic hepatitis B virus infection in Africans and variation in vitamin D receptor gene. J Infect Dis 179: 721-724 https://doi.org/10.1086/314614
  3. Bergstrom J (1989) Cigarette smoking as risk factor in chronic periodontal disease. Community Dent Oral Epidemiol 17: 245-247 https://doi.org/10.1111/j.1600-0528.1989.tb00626.x
  4. Bostein D, White RL, Skolnick M, and Davis RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 32: 314-331
  5. Chung DJ, Kim JM, Kim JY, Kim JY, Kim MS, Park JH, Yang SW, Chung MY, Lee TH, Park JT, Lee MY, Lee JH, and Choi C (1998) Vitamin D receptor gene polymorphisms and bone mineral density in Korean women. J Korean Soc Endocrinol 13: 394-409
  6. Collin HL, Uusitupa M, Niskanen L, Kontturi-Narhi V, Markkanen H, Koivisto AM, and Meurman JH (1998) Periodontal findings in elderly patients with non-insulin dependent diabetes mellitus. J Periodontol 69: 962-966 https://doi.org/10.1902/jop.1998.69.9.962
  7. Eisman JA (1996) Vitamin D receptor gene variants: implications for therapy. Curr Opin Genet Dev 6: 361-365 https://doi.org/10.1016/S0959-437X(96)80015-3
  8. Friedewald WT, Levy RI, and Fridrickson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clin Chem 18: 499-502
  9. Galbraith GM, Hendley TM, Sanders JJ, Palesch Y, and Pandey JP (1999) Polymorphic cytokine genotypes as markers of disease severity in adult periodontitis. J Clin Periodontol 26: 705-709 https://doi.org/10.1034/j.1600-051X.1999.t01-1-261101.x
  10. Genco RJ, Ho AW, Grossi SG, Dunford RG, and Tedesco LA (1999) Relationship of stress, distrees and inadequate coping behaviors to periodontal disease. J Periodontol 70: 711-723 https://doi.org/10.1902/jop.1999.70.7.711
  11. Grant SFA and Ralston SH (1997) Genes and osteoporosis. Trends Endocrinol Metab 8: 232-236 https://doi.org/10.1016/S1043-2760(97)00058-1
  12. Gross C, Eccleshall TR, and Feldman D (1996) Vitamin D receptor gene alleles and osteoporosis. In: Bilazikian JP, Raisz LG, and Rodan GA(eds), Principles of Bone Biology, Academic Press, San Diego, pp. 917-933
  13. Haffajee AD and Socransky SS (1994) Microbial ethiological agents of destructive peridontal diseases. J Periodontol 25: 78-111 https://doi.org/10.1111/j.1600-0757.1994.tb00020.x
  14. Hennig BJW, Parkhill JM, Chapple ILC, Heasman PA, and Taylor JJ (1999) Association of a vitamin D receptor gene polymorphism with localized early-onset periodontal diseases. J Periodontol 70: 1032-1038 https://doi.org/10.1902/jop.1999.70.9.1032
  15. Holla LI, Buckova D, Fassmann A, Halabala T, Vasku A, and Vacha J (2002) Promoter polymorphisms in the CD 14 receptor gene and their potential association with the severtiy of chronic periodontitis. J Med Genet 39: 844-848 https://doi.org/10.1136/jmg.39.11.844
  16. Holla LI, Fassmann A, Vasku A, Znojil V, Vanek J, and Vacha J (2001a) Interactions of lymphotoxin a (TNF-a), angiotensin-converting enzyme (ACE), and endothelin-1 (ET-1) gene polymorphisms in adult periodontitis. J Periodontol 72: 85-89 https://doi.org/10.1902/jop.2001.72.1.85
  17. Holla LI, Kankova K, Fassmann A, Buckova D, Halabala T, Znojil V, and Vanek J (2001b) Distribution of the receptor for advanced glycation end products gene polymorphisms in patients with chronic periodontitis: a preliminary study. J Periodontol 72: 1742-1746 https://doi.org/10.1902/jop.2001.72.12.1742
  18. Hustmyer FG, DeLuca F, and Peacock M (1993) Apa I, Bsm I, Eco RV and Taq I polymorphisms at the human vitamin D receptor gene locus in Caucasians, Blacks and Asians. Hum Mol Genet 2: 487 https://doi.org/10.1093/hmg/2.4.487
  19. Kang BY, Kim HH, and Lee KO (2003) The Pst I polymorphism of the human apolipoprotein AI gene in Korean elite athletes. Korean J Biol Sci 7: 69-73
  20. Kornman KS, Crane A, Wang HY, de Giovine FS, Newman MG, Pirk FW, Wilson TG Jr., Higginbottom FL, and Duff GW (1997) The interleukin-1 genotype as a severity factor in adult periodontal diseases. J Clin Periodontol 24: 72-77 https://doi.org/10.1111/j.1600-051X.1997.tb01187.x
  21. Lee CK, Hong JS, Cho YS, Yoo B, Kim GS, and Moon HB (2001) Lack of relationship between vitamin D receptor polymorphism and bone erosion in rheumatoid arthritis. J Korean Med Sci 16: 188-192 https://doi.org/10.3346/jkms.2001.16.2.188
  22. McDevitt MJ, Wang H-Y, Knovelman C, Newman MG, de Giovine FS, Timms J, Duff GW, and Kornman K (2000) Interleukin-1 genetic association with periodontitis in clinical practice. J Periodontol 71: 156-163 https://doi.org/10.1902/jop.2000.71.2.156
  23. Morrison NA (1997) Vitamin D receptor gene variants and osteoporosis: a contributor to the polygenic control of bone density. In: Feldman D (ed.), Vitamin D. Academic Press, San Diego, pp. 713-731
  24. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, and Eisman JA (1994) Prediction of bone density from vitamin D receptor alleles. Nature 367: 284-287 https://doi.org/10.1038/367284a0
  25. Rigby WF (1988) The immunobiology of vitamin D. Immunol Today 9: 54-58 https://doi.org/10.1016/0167-5699(88)91260-1
  26. Roy S, Frodsham A, Saha B, Hazra SK, Mascie-Taylor CGN, and Hill AVS (1999) Association of vitamin D receptor genotype with leprosy type. J Infect Dis 179: 187-191 https://doi.org/10.1086/314536
  27. Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito RB, and Line SR (2002) Investigation of an IL-2 polymorphism in patients with different levels of chronic periodontitis. J Clin Periodontol 29: 587-591 https://doi.org/10.1034/j.1600-051X.2002.290701.x
  28. Seysour GJ (1991) Importance of the host response in the periodontium. J Clin Periodontol 18: 421-426 https://doi.org/10.1111/j.1600-051X.1991.tb02310.x
  29. Sun JL, Meng HX, Cao CF, Tachi Y, Shinohara M, Ueda M, Imai H, and Ohura K (2002) Relationship between vitamin D receptor gene polymorphism and periodontitis. J Periodontol Res 37: 263-267 https://doi.org/10.1034/j.1600-0765.2002.01605.x
  30. Szpirer J, Szpirer C, Riviere M, Levan G, and Marynen P (1991) The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome 12q and rat chromosome 7. Genomics 11: 168-173 https://doi.org/10.1016/0888-7543(91)90114-T
  31. Taylor JA, Hirvonen A, Watson M, Pittman G, Mohler JL, and Bell DA (1996) Association prostate cancer with vitamin D receptor gene polymorphism. Cancer Res 56: 4180-4110
  32. Thompson WM, Enwards SJ, Dobson-Le DP, Tompkins GR, Poulton R, Knight DA, and Braithwaite AW (2001) IL-1 genotype and adult periodontitis among young New Zealanders. J Dent Res 80: 1700-1703 https://doi.org/10.1177/00220345010800080401
  33. Thorstensson H, and Hugoson A (1993) Periodontal disease experience in adult long-duration insulin-dependent diabetes. J Clin Periodontol 20: 352-358 https://doi.org/10.1111/j.1600-051X.1993.tb00372.x
  34. White CP, Morrison NA, Gardiner EM, and Eisman JA (1994) Vatamin D receptor alleles and bone physiology. J Cell Biochem 56: 307-314 https://doi.org/10.1002/jcb.240560306