한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제20권2호
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  • Pages.212-219
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  • 2003
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

임신 랫드에 투여한 GnRH와 HCG가 태아에 미치는 영향

Effects of the Administration of GnRH and HCG on the Fetus in Pregnant Rats

  • 발행 : 2003.06.01
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초록

The effect of GnRH and/or hCG on the implantation, pregnancy, and the concentration of plasma estradiol and progesterone were studied in pregnant rats. GnRH 50, or 100ug and/or hCG 50 or 100 IU were administered once on day 2 or 9 of gestation, respectively. Rats were autopsied on days 8 or 16. Administration of GnRH on day 2 did not induce the prevention of implantation and termination of pregnancy but was able to induce termination of pregnancy administering on day 9. Administration of hCG induced delayed implantation on day 2 and termination of pregnancy on day 2 and 9. Administration of GnRH concomitant with hCG had no effect on prevention of implantation on day 2 but induced termination of pregnancy with a very increased fetal resorption on day 2 and with a moderate increased fetal resorption on day 9. Administration of GnRH concomitant with hCG on day 2 induced more increased termination of pregnancy compared to injection of GnRH or HCG and opposite result was observed on day 9. Plasma estradiol and progesterone concentrations by administering GnRH and/or hCG had no effect on the termination of pregnancy the pregnant rats.

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참고문헌

  1. End Res Commum v.4 no.6 Pevention of implantation by [D-Trp6]-LH-RH in the rat: Comparative study with the effects of large doses of HCG on pregnancy Arimura,A.;Pedroza,E.;Vikchez-Martinez,J.;Schally,A.V. https://doi.org/10.3109/07435807709073628
  2. J Reprod Fert v.53 The role of placental gonadotrophins(PMSG and hCG)in pregnancy in the rat Bambra,C.S.;Gombe,S. https://doi.org/10.1530/jrf.0.0530109
  3. J Reprod Fert v.42 Pregnancy-terminating effect of Human Chorionic Gonadotrophin in rats Banik,U.K. https://doi.org/10.1530/jrf.0.0420067
  4. Biol Reprod v.16 Mechanism of the postcoital contraceptive effect of LH-RH in the Rat. 1. Serum hormone levels during chronic LH-RH administration Beattie,C.W.;Corbin,A.;Cole,G.;Corry,S.;Jones,R.C.;Koch,K.;Tracy,J. https://doi.org/10.1095/biolreprod16.3.322
  5. Contraception v.22 no.4 Luteolysis induced by a luteinizing hormone-releasing hormone agonist is prevented by human chorionic gonadotropin Bergquist,C.;Nilllius,S.J.;Wide,L. https://doi.org/10.1016/0010-7824(80)90019-0
  6. Endocrinology v.105 Mechanism of the postcoital contraceptive effect of luteinizing hormone-releasing hormone: ovarian luteinizing hormone receptor interactions Bex,F.J.;Corbin,A. https://doi.org/10.1210/endo-105-1-139
  7. J Endocr v.53 Plasma and pituitary luteinizing hormone concentrations and peripheral plasma oestradiol concentration during early pregnancy and after the administration of progestational steroids in the rat Brown-Grant K.;Corker,C.S.;Naftolin,F.
  8. Endocrinology v.95 Serum estrediol and prolactin concentrations in neonatal female rats treated with human chorionic gonadotrophin(HCG) Cheng,H.C.;Johnson,D.C. https://doi.org/10.1210/endo-95-5-1462
  9. Proc Soc Exp Biol v.144 Serum estradiol and progesterone concentrations in ovariectomized estrogen- and progesterone-primed and PMS-HCG-treated rats Colombo,J.A.;Hilliard,J.;Sawyer,C.H. https://doi.org/10.3181/00379727-144-37728
  10. Int J Fertil v.23 no.2 The anti-reproductive pharmacology of LH-RH and agonistic analogues Corbin,A.;Beattie,C.W.;Tracy,J.;Jones,R.;Foell,T.J.;Yardley,J.;Rees,R.W.A.
  11. Biol Reprod v.13 Serum progesterone in pregnant rats with ectopic or in situ corpora lutea: Correlation between amount of luteal tissue and progesterone concentration Elbaum,D.J.;Bender,E.M.;Brown,J.M.;Keyes,P.L. https://doi.org/10.1095/biolreprod13.5.541
  12. Biol Reprod v.24 Ovum transport in pregnant, pseudopregnant, and cyclic rats and its relationship to estradiol and progesterone blood levels Forcelledo,M.L.;Vera,K.;Croxatto,H.B. https://doi.org/10.1095/biolreprod24.4.760
  13. J Reprod Fert v.64 Antifertility effects of GnRH Fraser,H.M. https://doi.org/10.1530/jrf.0.0640503
  14. Anesthesiology v.65 Reproductive and teratogenic effects of lidocaine in Spragu-Dawley rats Fujinaga,M.;Mazze,R.I. https://doi.org/10.1097/00000542-198612000-00010
  15. J Reprod Fert v.13 Plasma progesterone concentrations during pregnancy and lactation in the rat Grota,L.J.;Eik-Nes K.B. https://doi.org/10.1530/jrf.0.0130083
  16. Contraception v.21 no.5 Studies on the mechanism of the antifertility activity of human chorionic gonadotropin in rodents Hahn,D.W.;Demers,L.M.;McGuire,J.L. https://doi.org/10.1016/0010-7824(80)90018-9
  17. J Clin Endocr Metab v.32 Effects of hCG and human pituitary LH on steroid secretion and functional life of the human corpus luteum Hanson,F.W.;Powell,J.E.;Stevens,V.C. https://doi.org/10.1210/jcem-32-2-211
  18. Endocr Rev v.2 Extrapituitary actions of gonadotropin-releasing hormone Hsueh,A.J.W.;Jones,P.B.C. https://doi.org/10.1210/edrv-2-4-437
  19. Biol Reprod v.16 The effects of luteinizing hormone releasing hormone(LH-RH) in pregnant rats. 1. Postnidatory effects Humphrey,R.R.;Windsor,B.L.;Reel,J.R.;Edgren,R.A. https://doi.org/10.1095/biolreprod16.5.614
  20. Biol Reprod v.19 The effects of luteinizing hormone releasing hormone(LHRH) in pregnant rats. 2. Prenidatory effects and delayed parturition Humphrey,R.R.;Windsor,B.L.;Jones,D.C.;Reel,J.R.;Edgren,R.A. https://doi.org/10.1095/biolreprod19.1.84
  21. Endocrionology v.90 Acute effect of gonadotrophins on the secretion of progestins by the rat ovary Ichikawa,S.;Morioka,H.;Sawada,T. https://doi.org/10.1210/endo-90-5-1356
  22. Endocronology v.113 Inhibition of implantation and termination of pregnancy in the rat by a human chorionic gonadotropin antagonist Kato,K.;Sairam,M.R.;Manjunth,P. https://doi.org/10.1210/endo-113-1-195
  23. J Endocrinol v.132 Daily administration of gonadotrophin- releasing hormone increases pituitary gonadotroph number and pituitary gonadotrophin content, but not serum gonadotrophin levels, in female rats on day of dioestrus Kotsuji,F.;Hosokawa,K.;Tominaga,T. https://doi.org/10.1677/joe.0.1320395
  24. Biol Reprod v.10 Temporal relationship between secretory patterns of gonadotrophins, estrognens, progestins, and prostaglandin-F in periparturient rats Labhsetwar,A.P.;Watson,D.J. https://doi.org/10.1095/biolreprod10.1.103
  25. J Reprod Fert v.17 Effect of chorionic gonadotrophin on the pre-implantation period of pregnancy in rats Mantalenakis,S.J. https://doi.org/10.1530/jrf.0.0170387
  26. Gynecol Obstet Invest v.24 The effect of a single dose of human chorionic gonadotropin at proestrus on embryonic mortality, fetal growth and gestation length in the rat Mattheij,J.A.M.;Heussen,H.;Linssen,P.C.M.L.;Swarts,J.J.M. https://doi.org/10.1159/000298788
  27. J Endocr v.44 The effect of exogenous gonadotrophins on the conceptus and corpus luteum in pregnant sheep Moor,R.M.;Rowson,L.E.A.;Hay,M.F.;Caldwell,B.V. https://doi.org/10.1677/joe.0.0440495
  28. Endocrinology v.92 Serum luteinizing hormone, prolactin and progesterone levels during pregnancy in the rat Morishige,W.K.;Pepe,G.J.;Rothchild,I. https://doi.org/10.1210/endo-92-5-1527
  29. Endocrinology v.95 A comparative study of serum progesterone levels on pregnancy and in various types of pseudopregnancy in the rat Pepe,G.J.;Rothchild,I. https://doi.org/10.1210/endo-95-1-275
  30. Acta Endocr v.69 Effect of HCG on plasma progesterone during the luteal phase of the menstrual cycle and during pregnancy Runnebaum,B.;Holzmann,K.;Bierwirth,A.M.;Munstermann,V.;Zander,J.
  31. J Endocr v.79 Secretion of progesterone during gestation in the rat Sanyal,M.K. https://doi.org/10.1677/joe.0.0790179
  32. Endocrinology v.78 Luteolytic effect of LH and HCG on the corpora lutea of pseudopregnant rabbits Spies,H.G.;Con,L.L.;Gier,H.T. https://doi.org/10.1210/endo-78-1-67
  33. Endocrinology v.75 Effect of gonadotrophins on corpora lutea of pseudopregnant rabbits Stormshok Fand Casida L.E. https://doi.org/10.1210/endo-75-3-321
  34. Biol Reprod v.25 In vivo and in vitro ovarian steroidogenesis in the pregnant rat Taya,K.;Greenwald,G.S. https://doi.org/10.1095/biolreprod25.4.683
  35. J Endocr v.65 Plasma hormones and pituitary luteinizing hormone in the rat during the early stages of pregnancy and after post-coital treatment with tamoxifen(ICI 46,474) Watson,J.;Anderson,F.B.;Alam,M.;O'Grady,J.E.;Heald,P.J. https://doi.org/10.1677/joe.0.0650007
  36. Endocrinology v.106 Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring Weisz,J.;Ward,I.L. https://doi.org/10.1210/endo-106-1-306
  37. Endocrinology v.87 Progesterone and 20α-hyroxypretn-4-en-3-one in plasma, ovaries and uteri during pregnancy in the rat Wiest,G.W. https://doi.org/10.1210/endo-87-1-43
  38. J Endocr v.99 Hormonal changes in the immature rat after administration of pregnant mare serum gonadotrophin: influence of body weight Wilson,C.A.;ter Haar,M.B.;Bonney,R.C.;Buckingham,J.;Dixon,A.F.;Yeo,T. https://doi.org/10.1677/joe.0.0990063
  39. Endocrionology v.83 Interruption in the rat and hamster by administration of PMS or HCG Yang;Chang https://doi.org/10.1210/endo-83-2-217
  40. Endocronology v.85 Estrogen secretion by the rat ovary in vitro during the estrous cycle and pregnancy Yoshinaga,K.;Hawkins,R.A.;Stocker,J.F. https://doi.org/10.1210/endo-85-1-103
  41. 한국수의공중보건학회지 v.20 no.2 임신랫드에 투여한 HCG가 Estrogen과 Progesterone 또는 Na와 K의 농도에 미치는 영향 김영홍