Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Swelling Behavior and Mechanical Strength of Crosslinked Dextran Hydrogel

  • Kim, Byung-Hoon (Faculty of Applied Chemical Engineering and the Engineering Research Institute, Chonnam National University) ;
  • Kim, Do-Man (Faculty of Applied Chemical Engineering and the Engineering Research Institute, Chonnam National University) ;
  • Jung, Yong-Sik (Faculty of Applied Chemical Engineering and the Engineering Research Institute, Chonnam National University) ;
  • Kim, Hoon (Faculty of Applied Chemical Engineering and the Engineering Research Institute, Chonnam National University) ;
  • Cho, Dong-Lyun (Faculty of Applied Chemical Engineering and the Engineering Research Institute, Chonnam National University)
  • Published : 2003.08.31
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Abstract

Dextran as a candidate material for colon-specific drug delivery has been studied. Crosslinked dextran hydrogels were prepared by mixing dextran, $MgCl_2$, glutaraldehyde (GA) and polyethyleneglycol (PEG 400) in water. The dextran hydrogels were characterized by measuring equilibrium swelling ratios and mechanical strengths. Response surface methodology (Central Composite Design) was used to evaluate the swelling behaviors and mechanical strengths as functions of concentrations of $MgCl_2$, GA, and PEG 400, which was found to be useful for the evaluation. It showed that the swelling behavior and mechanical strengths were influenced significantly by PEG 400 and $MgCl_2$ concentrations.

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References

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