The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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The Effect of TENS on Substance P Expression in Arthritis-Induced Rat Spinal Cord

TENS가 관절염으로 유발된 흰쥐 척수내 Substance-P 발현에 미치는 영향

  • Lee Mi-Ae (Department of physical Therapy, Maryknoll general hospital) ;
  • Kim Jin-Sang (Department of Physical Therapy, College of Rehabilitation Science, Taegu University) ;
  • Baek Su-Jeong (Major in Physical Therapy, Dept. of Rehabilitation Science, Graduate School, Taegu University)
  • 이미애 (부산 메리놀병원 물리치료실) ;
  • 김진상 (대구대학교 재활과학대학 물리치료학과) ;
  • 백수정 (대구대학교 대학원 재활과학과 물리치료진공)
  • Published : 2003.12.01
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Abstract

The purpose of this study is to investigate and analysis effect of TENS with immunohistochemistry methode through changes of substance P in spinal using arthritis model after inducing inflammation. The changes of substance P induced at that time are compared with control which is not induced arthritis by means of counting. The effect of TENS (4Hz, $200{\mu}$, 20minutes) is also tested by observing changes of substance P in spinal dorsal horn after application on knee joint of rats which is arthritis model induced by kaolin and carrageenan. The results of this study were as follows: 1. Substance P immunoreactive positive neurons are increased in dorsal horn after inducting arthritis. 2. In arthritis group, Substance P immunoreactive positive neurons are progressively increased from the first to the third days. 3. Substance P immunoreactive positive neurons after applicating TENS on arthritis group are more decreased than only arthritis-induced group. 4. Substance P immunoreactive positive neurons were significantly decreased on the second days resulting from TENS application from the first to the third days. Therefore, TENS application is decrease Substance P immunoreactive positive neurons in spinal dorsal horn of rats induced arthritis. This decrease is considered as analgesic effect of TENS.

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