Journal of Gastric Cancer

The Korean Gastric Cancer Association (대한위암학회)
권호 표지

Expression Pattern of Caspase 2 in Korean Gastric Cancers

한국인 위암에서 Caspase 2 단백 발현 양상

  • Kim, Chang-Jae (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Park, Jik-Young (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Lee, Jong-Heun (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Cho, Young-Gu (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Lee, Jong-Woo (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Song, Young-Hwa (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Kim, Young-Sil (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Park, Cho, Hyun (Departments of Surgery, Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Nam, Suk-Woo (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Lee, Sug-Hyung (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Yoo-Nam-Jin (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Park, Won-Sang (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea) ;
  • Lee, Jung, Young (Departments of Pathology Medical Research Center, College of Medicine, The Catholic University of Korea)
  • 김창재 (가톨릭대학교 의과대학 병리학교실) ;
  • 박직영 (가톨릭대학교 의과대학 병리학교실) ;
  • 이종흔 (가톨릭대학교 의과대학 병리학교실) ;
  • 조용구 (가톨릭대학교 의과대학 병리학교실) ;
  • 이종우 (가톨릭대학교 의과대학 병리학교실) ;
  • 송영화 (가톨릭대학교 의과대학 병리학교실) ;
  • 김영실 (가톨릭대학교 의과대학 병리학교실) ;
  • 박조현 (가톨릭대학교 의과대학 외과학교실) ;
  • 남석우 (가톨릭대학교 의과대학 병리학교실) ;
  • 이석형 (가톨릭대학교 의과대학 병리학교실) ;
  • 유남진 (가톨릭대학교 의과대학 병리학교실) ;
  • 박원상 (가톨릭대학교 의과대학 병리학교실) ;
  • 이정용 (가톨릭대학교 의과대학 병리학교실)
  • Published : 2003.03.01
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Abstract

Purpose: Caspase 2, a member of the family of ICE-like proteases, is activated by the Fas pathway and induces apoptosis by triggering the caspase cascade. The purpose of this study was to determine whether the expression pattern of caspase 2 might be associated with gastric cancer development and if so, to determine to which pathologic parameter it is linked. Materials and Methods: For the construction of the gastric cancer tissue microarray, 78 paraffin-embedded tissues containing gastric cancer areas were cored 3 times and transferred to the recipient master block. The expression pattern of caspase 2 was examined on tissue microarray slides by using immunohistochemistry and was compared with pathologic parameters, including histologic type, depth of invasion, lymph node metastasis, and peritoneal dissemination. Results: Caspase 2 was expressed on superficial and foveolar epithelial cells and lymphocytes in the gastric mucosa, mainly in cytoplasm. We found loss of caspase 2 expression in 41 ($52.6\%$) of the 78 gastric cancer tissues. Statistically, histologic type and other pathologic parameters were not related with loss of caspase 2 expression Conclusion: Our findings provide enough evidence that loss of caspase 2 expression may contribute to the development of Korean gastric cancer and that it might be one of the possible escape mechanisms from apoptosis in gastric cancer.

Keywords