References
- Gowen M, Wood DO, Ihrie EJ, McGuire MK, Russell RG. An interleukin 1 like factor stimulates bone resorption in vitro. Nature 1983 : 306 : 378-80
- Bertolini DR, Nedwin GE, Bringman TS, Smith DD, Mundy GR. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumor necrosis factors. Nature 1986 : 319 : 516-8
- Lowenstein CJ, Snyder SH. Nitric oxide, a novel biologic messenger. Cell 1992 : 70 : 705-7
- Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992 : 6 : 3051-64
- Devlin AM, Brosnan MJ, Graham D, Morton JJ, McPhaden AR, Mclntyre M, Hamilton CA, Reid JL, Dominiczak A. Vascular smooth muscle cell polyploidy and cardiomyocyle hypertrophy due to chronic NOS inhibition in vivo. Am J Physiol 1998 : 274 : H52-9
- Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 1991 : 351 : 714-8
- Lamas S, Michel T, Collins T, Brenner BM, Marsden PA. Effects of interferon-gamma on nitric oxide synthase activity and endothelin-1 production by vascular endothelial cells. J Clin Invest 1992: 90 : 879-87
- Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages, Science 1992 : 256 : 225-8
- Macintyre I, Zaidi M, Alam AS, Datta HK, Moonga BS, Lidbury PS, Hecker M, Vane JR. Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP. Proc Nail Acad Sci USA 1991 : 88 : 2936-40
- Kasten TP, Collin-Osdoby P, Patel N, Osdoby P, Krukowski M, Misko TP, Settle SL, Currie MG, Nickols GA. Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase. Proc Natl Acad Sci USA 1994 : 91 : 3569-73
- Lwik CW, Nibbering PH, Van de Ruit M, Papapoulos SE. Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption. J Clin Invest 1994 : 93 : 1465-72
- Damoulis PD, Hauschka PV. Cytokines induce nitric oxide production in mouse osteoblasts. Biochem Biophys Res Commun 1994: 201 :924-31
- Damoulis PD, Hauschka PV. Nitric oxide acts in conjunction with proinflammatory cytokines to promote cell death in osteoblasts. J Bone Miner Res 1997: 12 : 412-22
- Ralston SH, Grabowski PS. Mechanisms of cytokine induced bone resorption: role of nitric oxide, cyclic guanosine monophosphate, and prostaglandins. Bone 1996 : 19 : 29-33
- Chae HJ, Park RK, Chung HT. et. al. Nitric oxide is a regulator of bone remodelling. J Pharm Pharmacol 1997 : 49 : 897-902
- Akira S, Hirano T, Taga T, Kishimoto T, Biology of multifunctional cytokines : IL 6 and related molecules (IL 1 and TNF). FASEB J 1990: 4: 2860-7
- Van Snick J. Interleukin-6 : an overview, Annu Rev Immunol 1990: 8: 253-78
- Hughes FJ, Howells GL. Interleukin-6 inhibits bone formation in vitro, Bone Miner 1993 : 21 : 21-8
- Roodman GD. lnterleukin-6: an osteotropic factor? J Bone Miner Res 1992 : 7 : 475-8
- Feyen JH, Elford P, Di Padova FE, Trechsel U. Interleukin-6 is produced by bone and modulated by parathyroid hormone. J Bone Miner Res 1989 : 4 : 633-8
- Ishimi Y, Miyaura C, Jin CH. et. al. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 1990:145: 3297-303
- Franchimont N, Canalis E. Platelet-derived growth factor stimulates the synthesis of interleuktn-6 In cells of the osteoblast lineage. Endocrinology 1995 : 136: 5469-75
- Bhat NR, Zhang P, Lee JC, Hogan EL. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase andtumor necrosis factor-gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 1998: 18 : 1633-41
- Da Silva J, Pierrat B, Mary JL, Lesslauer W. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. J Biol Chem 1997 : 272: 28373-80
- Stuehr DJ, Nathan CF. Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med 1989: 169: 1543-55
- Kozawa O, Tokuda H, Matsuno H, Uematsu T. Involvement of p38 mitogen-activated protein kinase in basic fibroblast growth factor-induced interleukin-6 synthesis in osteoblasts, J Cell Biochem 1999 : 74 : 479-85
- MacKenna DA, Dolfi F, Vuori K, Ruoslahti E. Extracellular signalregulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integnn-dependent and matrix-specific in rat cardiac fibroblasts. J Clin Invest 1998: 101 : 301-10
- Lee JC, Laydon JT, McDonnell PC, et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis, Nature 1994 : 372 : 739-46
- Cuenda A, Rouse J, Doza YN. et. al, SB 203580 is a specific inhibiter of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 1995 : 364 : 229-33 https://doi.org/10.1016/0014-5793(95)00357-F
- Moncada S, Higgs A. The L-arginine-nitric oxide pathway, N Engl J Med 1993: 329: 2002-12
- Chae HJ, Park RK, Kang JS, et. al. Effect of stem cell factor, Interleukin-6, nitric oxide andtransforming growth factor-beta on the osteoclast differentiation induced by 1,25-(OH)2D3 in primary murine bone marrow cultures, Pharmacol Toxicol 1998 : 82 : 223-9
- Griswold DE, Hillegass LM, Meunier PC, DiMartino MJ, Hanna N, Effect of inhibitors of eicosanoid metabolism in murine collageninduced arthritis, Arthritis Rheum 1988: 31 : 1406-12
- Badger AM, Bradbeer IN, Votta B, et. al. Pharmacological profile of SB203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function, J Pharmacol Exp Ther 1996 : 279 : 1453-61
- Votta BJ, Bertolini DR, Cytokine suppressive anti-inflammatory compounds inhibit bone resorption Invitro, Bone 1994 : 15 : 533-8
- Young P, McDonnell P, Dunnington D. et. al. Pyridlnyl imidazoles inhibit IL-1 and TNF production at the protein level, Agents Actions 1993: C67-9
- Mcinnes IB, Leung BP, Field M, et. ai, Production of nitric oxide in thesynovial membrane of rheumatoid and osteoarthritis patients. J Exp Med 1996: 184: 1519-24
- Ray A, LaForge KS, Sehgal PB, On the mechanism for efficient repression of interleukin-6 promoter by glucocorticoids: enhancer, TaTa box, and RNA start site (tnr motif) occlusion, Mol Cell Biol 1990 : 10 : 5736-46
- Libermann TA, Baltimore D. Activation of interleukin-6 gene expression through the NF-B transcription factor, Mol Cell Biol 1990: 10 : 2327-34
- Zhang Y, Lin JX, Vilcek J, Interleukin-6 induced by tumor necrosis factor and Interleukine-1 in human fibroblasts involves activation of a nuclear factor binding to a B-like sequence, Mol Cell Biol 1990: 10: 3818-23
- Wim VB, Stephane P, Elke B, Karolien DBM, Lienhard, S, Walter F, Guy H, p38 and extracellular signal-regulated kinase mitogenactivated protein kinase pathways are required for nuclear factor-B p65 transactivation mediated by tumor necrosis factor. J Biol Chem 1998 : 273 : 3285-90
- Han J, Lee JD, Bibbs L, Ulevitch RJ, A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Science 1994 : 265 : 808-11
- Rouse J, Cohen P, Trigon S. et. al. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins, Cell 1994 : 78: 1027-37