The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
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Detection of Platelet Aggregation Inhibitors and Fibrinolytic Substances from Mushrooms

버섯류로부터 혈소판 응집억제물질과 혈전용해물질의 탐색

  • Park, Jeong-Sik (National Institute of Agricultural Science and Technology) ;
  • Hyun, Kwang-Wook (Department of Genetic Engineering and Bio-med RRC, Paichai University) ;
  • Seo, Seung-Bo (Hankook Sin Yak Pharma. Co.) ;
  • Cho, Soo-Muk (National Rural Living Science Institute) ;
  • Yoo, Chang-Hyun (National Institute of Agricultural Science and Technology) ;
  • Lee, Jong-Soo (Department of Genetic Engineering and Bio-med RRC, Paichai University)
  • Published : 2003.08.30
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Abstract

Platelet aggregation inhibitory and fibrinolytic activities of water and ethanol extracts from mushrooms were studied. The highest platelet aggregation inhibitory activity was 81.2% in the ethanol extract from fruiting body of Inonotus obliquus ASI 74006 and also were high in the ethanol extract from fruiting bodies of Fomitella fraxinea. The ethanol extract from the mycelia of Agaricus blazei Murill. ASI 1174 showed the strongest fibrinolytic activity as 9.6 unit. However fibrinolytic activities of other mushrooms were low or negligible.

농업과학기술원에서 분양 받은 52종의 버섯류의 자실체와 균사체들의 물 추출물과 에탄올 추출물에 대한 혈소판 응집억제 활성과 혈전용해활성을 조사하였다. 차가버섯 ASI 74006 균사체의 에탄올 추출물이 81.2%로 가장 높은 ADP 유도 혈소판 응집 억제활성을 보였고 그 다음은 장수버섯 자실체 에탄올 추출물들이 높았다. 그리고 혈전용해활성은 신령버섯 ASI 1174 균사체의 에탄올 추출물이 9.6 unit로 가장 높았으며 다른 버섯류는 대체로 낮았다.

Keywords

References

  1. 한국균학회지 버섯으로부터 항고혈압성 안지오텐신 전환효소 저해제의 탐색 이대형;김재호;공원식;유영복;박정식;유창현;이종수
  2. Kor. J. Food. Sci. Technol. v.31 Screening of mushrooms having fibrinolytic activity Choi, N.S.;Seo, S.Y.;Kim, S.H.
  3. J. Antibiotics v.45 Antibiotics from Basidiomycetes XLI, clavicoronic acid, A novel inhibitor of reverse transcriptase from Clavicorona pyxidate Erkel, G.;Anke, T. https://doi.org/10.7164/antibiotics.45.29
  4. B. subtilis. Zeit. Fun. Allgem. Mikrobiol. v.20 Purificatin and properities of fibrinolytic enzyme Fayek, K.I.;El-Sayed, S.T.
  5. J. Nutr. Sci. Vitaminol. v.34 Dietar effect of Ganoderma lucidum: Mushroom on blood pressure and lipid levels in spontaneously hypertentive rats(SHR) Kabir, Y.;Kimura, S.;Tamura, T.
  6. Biol. Pharm. Bull. v.16 Polysaccharides in fungi. XXXII. Hypoglycemic activity and chemical properties of a polysaccharide from the culture mycelim of Cordyceps sinensis Kiho, T.;Hui, J.;Yamane, A.;Ukai, S. https://doi.org/10.1248/bpb.16.1291
  7. Basic medical biochemistry Marks, D.;Marks, A.;Smith, C.
  8. Food Reviews International v.59 Antitumore-activity heteroglycans from niohsimeji, Tricholoma giganteum Mizuno, T.;Kinoshit, T.;Zhung, C.;Ito, H.;Mayuzumi, Y.
  9. Biochem. v.30 Cordycepin analogues of 25-oligoadenylate inhibitor human immunodeficiency virus infection via inhibition of reverse transcriptase Muller, W.E.G.;Weiler, B.E.;Charubala, R.W.;Schroder, H.C.
  10. Mycelial new material; Food Functional Technology Yang, H.C.;Song, C.H.;Kweon, M.H.

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