Effects of Dioscorea batatas on Estrogen-deficient Osteoporosis

Estrogen 결핍성(缺乏性) 골다공증(骨多孔症)에 미치는 산약(山藥) 추출물(抽出物)의 영향(影響)

  • Hwang Gwi-Seo (College of Oriental Medicine, Kyungwon University) ;
  • Lee Dae-Young (College of Oriental Medicine, Kyungwon University)
  • 황귀서 (경원대학교 한의과대학) ;
  • 이대영 (경원대학교 한의과대학)
  • Published : 2003.06.29

Abstract

Osteoporosis is characterized by bone loss and mobidity with osteoporotic fracture. This study was performed to evaluate the effect of on the bone mass and its related factors in estrogen-deficient animal model. The model rats of osteoporsis showed a significant decrease in bone density, bone ash density, calcium content of femur bone. At the 14th day after ovariectomy-surgery, rats were administered with DBE, extract of Dioscorea batatas, per orally, and continued for 10 weeks. And osteoporosis related parameters were determined to investigate the effect of DBE. Osteoporetic rats showed lower serum estrogen level, higher body weight than normal rats, and showed atrophy of uterine horns. DBE showed inhibitory effect on bone loss in osteoporetic condition, and reduced the increase of ALP activity and osteocalcin level in serum, and reduced the increase of OH-proline level in urine. But, DBE had no effect on cell proliferation and ALP activity in rat calvarial cell culture.

Keywords

References

  1. Bone v.19 Effect of hormone replacement therapy on canxellous bone microstructure in postmenopausal woman Vedi, S.;Croucher, P.I.;Garrahan, N.J.;Compston, J.E.
  2. J. Clin. Endocri. Met. v.81 Mechanisms of glucocorticoid Action in Bone : Implications to gluco-corticoid-induced Osteoporosis Canalis, E.
  3. J. Clin. Endocri. Met. v.81 Effect of growth hormone and insulin-like growth factor I in men with idiopathic osteoporosis Johansson, A.G.;Lindah, E.;Blum, W.F.;Kollerup, G.(et al.)
  4. J. Bone. Mener. Res. v.11 Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis Pacifici, R.
  5. 中藥大辭典 v.2
  6. 生藥學 韓大錫
  7. Folia Microbial. Praha. v.41 Aderiya, B.I.(et al.)
  8. Planta Med. v.62 Hu, K.(et al.)
  9. Planta Med. v.52 Hikino, H.(et al.)
  10. Life Sci. v.59 Arghiniknam, M.(et al.)
  11. J. Ethnopharmacol. v.15 Undie, A.S.(et al.)
  12. 東醫生物療法科學 林準圭(外)
  13. 黃帝內經素問今釋 王奇(外)
  14. 東醫寶鑑 許浚
  15. 診療要鑑 上 金定濟
  16. 東醫再活醫學科學 全國 漢醫科大學 再活醫學科 敎授室(篇)
  17. 韓方專門醫叢書 이명식(外)
  18. 外科病實用方 許芝銀(外)
  19. 實用中西醫結合診斷治療學 陳貴廷(外)
  20. 原色最新大百科事典 新太陽社 編輯局 百科事典部
  21. 靈樞經校釋 河北醫學院校釋
  22. 傷寒論臨床實驗錄 那錫波
  23. 東垣十書醫書 李東垣
  24. 六科證治準繩 醫部全錄 v.5 王肯堂
  25. 景岳全書 張介賓
  26. 實用中醫內科學 顧伯華
  27. Osteoporosis Int. Biochemical markers of bone turnover for the clinical investigation of osteoporosis Delmas, P.D.
  28. J. Bone Mineral Res. v.8 Immunoassay of pyridinoline crosslinks excretion in normal adults and in paget's disease Delmas, P.D.;Gineytes, E.;Bertholin, A.;Garnero, P.;Marchand, F.
  29. Biochem Biophys. Res. Commun. v.162 Parathyroid hormone (PTH) and PTH-like protein(PLP) stimulate interleukin-6 production by osteogenic cells : A possible role of interleukin-6 in osteoclastogenesis Lowik, C.W.;Pluijm, G.;Bloys, H.;Hoekman, K.;Bijvoet, O.L.;Aarden, L.A.;Papapoulos, S.E.
  30. Bone v.9 Osteoclastic bone resorption : in Vitro analysis of the rate of resorption and migration of individual osteoclasts Kanehisa, J.;Heersche, J.N.
  31. Endocrinology v.125 Calcitonin receptors as markers for osteoclastic differentiation : Correlation between generation of bone resorptive cells that express calcitonin receptors in mouse bone marrow cultures Hattersley, G.;Chambers, T.J.
  32. J. Clin. Endocrinol. Metab. v.62 Serum osteocalcin is increased in patients with hyperthyroidism and decreased in patients receiving glucocorticoids Lukert, B.P.;Higgins, J.C.;Stoskopf, M.M.
  33. Ann. Intern. Med. v.87 Effect of estrogens and calcium carbonate on bone loss in postmenopausal woman Recker, R.R.;Salville, P.D.;Heaney, R.P.
  34. Arch. Otorhinolayngol v.242 The effect of flavone treatment on human oscleoretic ossicle organ culture Sziklai, I.;Ribari, P.
  35. J. Bone Miner. Res. v.6 Effects of ipriflavone and its metabolites on a clonal osteoblastic cell line Benvennuti, S.;Tanini, A.;Frediani, U.;Bianchi, S.;Masi, L.;Casano, R.;Buffalino, L.;Serio, M.;Bradi, M.L.
  36. Life Sci. v.38 Effect of ipriflavone on glucocorticoid-induced osteoporosis in rats Yamazaki, I.;Shino, A.;Shimizu, Y.;Tsukuda, R.;Shiakawa, Y.;Kinoshita, M.