Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Vasodilation Effect of the Water Extract of Gingko biloba, Acanthopanax senticosus and Augmented Four-Substance Decoctions in Rat Thoracic Aorta

백과엽(白果葉) 및 자오가(刺五加) 가미사물탕(加味四物湯)이 백서(白鼠)의 흉부대동맥(胸部大動脈) 혈관이완(血管弛緩)에 미치는 영향

  • Kim Hyung-Hwan (Vascular Medicine Research Unit, Cardiovascular Division, Brigham & Women's Hospital and Harvard Medical School) ;
  • Park Soo-Yeon (Research institute of Physical education, Kyung Hee Univ.) ;
  • Kang Soon-Ah (Dept. of Applied Biology & Chemistry, Konkuk University) ;
  • Kim Hong-Yeoul (Institute of Oriental Medicine, Kyung Hee University) ;
  • Ahn Duk-Kyun (Jaseng research institute of biotechnology & bioscience) ;
  • Park Seong-Kyu (College of Oriental Medicine, Kyung Hee University)
  • 김형환 (하버드대학교 의과대학 여성병원 혈관의학연구실) ;
  • 박수연 (경희대학교 체육과학연구소) ;
  • 강순아 (건국대학교 응용생물화학과 생명분자정보학센터) ;
  • 김홍렬 (경희대학교 한의학연구소) ;
  • 안덕균 (자생생명공학연구소) ;
  • 박성규 (경희대학교 한의과대학)
  • Published : 2003.12.30
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Abstract

We have examined the relaxational response to the water extract of Angelica gigas $N_{AKAI}$ (AG), Gingko biloba $L_{INNE}$ (GB), Acanthopanax senticosus $H_{ARMS}.$ (AP) and Augumented-Four-Substance Decoction (AG-FSD, GB-FSD, AP-FSD) in isolated thoracic aorta from sprague dawley(SD) rat. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT) were compared in vasodilation effect. We found that the thoracic aorta segments responded to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD with a dose-dependent vasodilation. The 5-hydroxytryptamine induced contraction at $10^{-4}M$ were inhibited by 26.3%, 75.8%, 87.5% and 6.9%, 22.6%, 30.8% after addition of the 0.1 g/mL water extract of AG, GB, AP and AG-FSD, GB-FSD, AP-FSD. In conclusion, AG, GB, AP and AG-FSD, GB-FSD, AP-FSD induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. AP-FSD has very potent vasodilation.

Keywords

References

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