Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제29권5호
  • /
  • Pages.293-297
  • /
  • 2003
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

만성 미만성 경화성 골수염을 동반한 개화성 백악질-골 이형성증의 면역조직화학적 연구

AN IMMUNOHISTOCHEMICAL STUDY ON CALCIFYING TISSUES OF THE FLORID CEMENTO-OSSEOUS DYSPLASIA EASILY INVOLVING CHRONIC DIFFUSE SCLEROSING OSTEOMYELITIS

  • 김지혁 (강릉대학교 치과대학 구강악안면외과학 교실 및 구강과학연구소) ;
  • 조정애 (강릉대학교 치과대학 구강악안면외과학 교실 및 구강과학연구소) ;
  • 김성민 (강릉대학교 치과대학 구강악안면외과학 교실 및 구강과학연구소) ;
  • 박영욱 (강릉대학교 치과대학 구강악안면외과학 교실 및 구강과학연구소) ;
  • 허진영 (아산강릉병원 치과) ;
  • 이석근 (강릉대학교 치과대학 구강병리학 교실)
  • Kim, Ji-Hyuck (Department of Oral & Maxillofacial Surgery and Research Institute of Oral Science, College of Dentistry, Kangnung National University) ;
  • Jo, Joung-Ae (Department of Oral & Maxillofacial Surgery and Research Institute of Oral Science, College of Dentistry, Kangnung National University) ;
  • Kim, Soung-Min (Department of Oral & Maxillofacial Surgery and Research Institute of Oral Science, College of Dentistry, Kangnung National University) ;
  • Park, Young-Wook (Department of Oral & Maxillofacial Surgery and Research Institute of Oral Science, College of Dentistry, Kangnung National University) ;
  • Huh, Jin-Young (Department of Dentistry, Asan Gangneung Hospital) ;
  • Lee, Suk-Keun (Department of Oral Pathology, College of Dentistry, Kangnung National University)
  • 발행 : 2003.10.30
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초록

Florid cemento-osseous dysplasia (FCOD) is a benign, non-neoplastic lesion characterized by multiple sclerosing masses only within jawbones. It is frequently confused with chronic diffuse sclerosing osteomyelitis (CDSO) in previous literatures. In our study, two cases of FCOD were examined to know the characteristics of their calcifying tissues. The first case was non-infected, while the second case was severely infected, displaying the typical features of CDSO in clinico-radiologic findings. The infected FCOD case showed a lot of bacterial colonies in the main lesion with relatively rare inflammatory reaction. The globular cementum-like materials of FCOD showed woven bone pattern and was positive for Alcian blue stain, and also positive for the antibodies of ameloblastin, bone morphogenetic protein (BMP) -2 and -4. On the other hands, in the immunostains of matrix metalloproteinase (MMP) -3, -9, -10, and $TNF-{\alpha}$, macrophage infiltrated in the FCOD lesion was rarely observed. These data suggest that the cementum-like materials of FCOD contain various matrix proteins, and that the cementum-like materials are relevant to the overgrowth of the bacterial colonies by inhibition of the regional inflammatory reactions.

키워드

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