Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

A psycho-pharmacological study of BRHAT VATACINTAMANI RASA classical ayurvedic drug

  • Islam, M. Naimul (Ethnopharmacology Laboratory, Department of Pharmacy, Jahangirnagar University) ;
  • Sattar, Mafruhi (Ethnopharmacology Laboratory, Department of Pharmacy, Jahangirnagar University) ;
  • Haque, Sabera (Ethnopharmacology Laboratory, Department of Pharmacy, Jahangirnagar University) ;
  • Shahriar, Masum (Department of Pharmacy, Gono Bishwabidyalay) ;
  • Choudhuri, Msk (Ethnopharmacology Laboratory, Department of Pharmacy, Jahangirnagar University)
  • Published : 2003.05.30
Download PDF
⟨ Previous Next ⟩

Abstract

The psycho-pharmacological effect of BRHAT VATACHINTAMANI RASA (BVC) an Ayurvedic preparation was investigated, both in animal and clinical models. It was observed that BVC possess a sedative or quitening effect in that it significantly decreased the spontaneous motor activity, and also lowered the exploratory behavior of the amphetamine treated animals. This was further evident by increase in climbing out time and taming effect on animal in isolation induced aggression test. Apart from very high dose it seems have little effect on pentobarbital sleeping time and narcotic analgesic test. The drug BVC increases performance of the animal in forced locomotor test. The effect of VATACHINTAMANI RASA on clinical study was not significant.

Keywords

References

  1. Anonymous. (1948) Report of the Committee on Indigenous System of Medicine Ministry of Health; Government of India. 11, 347.
  2. Biological Psychology Kalat, James W, 2nd Edn. p. 311.
  3. Bowman WC, Rand MJ(1980a). Textbook of Pharmacology, 2nd Edn, pp. 11.38.
  4. Bowman WC, Rand MJ(1980b). Textbook of Pharmacology, 2nd Edn. pp. 8.5.
  5. Bowman WC, Rand MJ (1980c). Textbook of Pharmacology, 2nd Edn. pp. 17.33.
  6. Bowman WC, Rand MJ (1980d). Textbook of Pharmacology, 2nd Edn. pp. 16.1.
  7. Dasa, Govinda; Bhaisajya ratnavali; revised and edited by Kaviraj Narendranath Mitra, Jayadeva Vidyalankar Haridatta Sastri, Talchandraji Vaidya; Varanasi; Motilal Benarasi Das. Samvat 2019, pp. 502-503.
  8. Dunham NW, Miya TS. (1957) A Note on the Simple Apparatus for Detecting Neurological Deficit in Rats and Mice; 1. Amer. Pharm. Assoc. Sci. 46, 208-209. https://doi.org/10.1002/jps.3030460322
  9. Ghosh S, Kar SK. (1966) Clinical trial on brahmi - Part II; Pharmacological Investigations with Normals. J. Expt. Med. Sci. 10, 12-14.
  10. Janssen PAJ, genean AH, Niemegeers CIE. (1960) 1. pharmacol. 129, 471.
  11. Kalat JW. (1984) Biological Psychology, 2nd Edn, pp. 313, Wadsworth Publishing Co.
  12. Kobayashi T, Tobe A. (1976) Pharmacological Studies on Triazine Derivatives V. Japan J. pharmacol. 26, 559-570. https://doi.org/10.1254/jjp.26.559
  13. Ruch JC. (1984) Psychology: The Personal Science, pp. 212, Wadsworth Publishing Co.
  14. Sandberg F. (1957) A Comparative Quantitative Study of the Central Depressant Effects of Seven Clinically Used Phenothiazine Derivatives. ArzneimiHel forschung 9, 203-206.
  15. Siegmund PN, Wolf M. (1952) Displacement of Sand Method for the Determination of Locomotor Activity. Arch. Exp. Pathol. Pharmacol. 216, 232-235.
  16. Tedeschi DW, Tedeschi RE. (1968) Importance of Fundamental Priciples in Drug Evaluation, pp. 307-324, Raven Press, New York.
  17. Vane JR. (1961) Tryptamine Receptors in the Central Nervous System. Nature 191, 1068-1069. https://doi.org/10.1038/1911068a0
  18. Woolfe G, MacDonald AD. (1944) J. Phannacol. Exper. Therp. 80, 300.
  19. Yen HCY, Stanger R, Millman N. (1958) 1. Pharmacol. 122, 85A.