Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Action of enzyme food, Green Life Enzyme on systemic and local anaphylaxis

  • Moon, Phil-Dong (Department of Oriental Pharmacy, College of Pharmacy, and Korea Institute of Oriental Pharmacy, Wonkwang University) ;
  • Na, Ho-Jeong (Department of Oriental Pharmacy, College of Pharmacy, and Korea Institute of Oriental Pharmacy, Wonkwang University) ;
  • Kim, Hyung-Min (Department of Oriental Pharmacy, College of Pharmacy, and Korea Institute of Oriental Pharmacy, Wonkwang University)
  • Published : 2003.02.28
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Abstract

We studied the inhibitory effect of Green Life Enzyme (GLE) on compound 48/80-induced anaphylactic response in a murine model. GLE inhibited compound 48/80-induced systemic anaphylactic shock at the dose of 10 g/kg by 87.5%. When GLE was given as pre-treatment at concentrations ranging from 0.01 to 1.0 g/kg, it inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. In addition, GLE (0.1 mg/ml) inhibited anti-DNP IgE-induced tumor necrosis $factor-{\alpha}$ production from mast cells by 69% compared to saline value. These results indicate that GLE may possess anti-anaphylactic and anti-inflammatory activity.

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