Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Physicochemical Properties of Poloxamer-based Gel Containing Capsaicin Analog

캡사이신유도체를 함유하는 폴록사머 겔제제의 물리화학적 특성

  • Kim, Tae-Wan (College of Pharmacy, Kangwon National University) ;
  • Cao, Qing-Ri (College of Pharmacy, Kangwon National University) ;
  • Choi, Chun-Young (College of Pharmacy, Kangwon National University) ;
  • Lee, Beom-Jin (College of Pharmacy, Kangwon National University)
  • 김태완 (강원대학교 약학대학 생체리듬 및 제어방출 연구실) ;
  • 조청일 (강원대학교 약학대학 생체리듬 및 제어방출 연구실) ;
  • 최춘영 (강원대학교 약학대학 생체리듬 및 제어방출 연구실) ;
  • 이범진 (강원대학교 약학대학 생체리듬 및 제어방출 연구실)
  • Published : 2003.03.20
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Abstract

Physicochemical changes of poloxamer-based gel containing capsaicin analog (N-[3-(3,4-dimethylphenyl)propyl]-4-(2-aminoethoxy)-3-methoxyphenyl acetamide) such as drug content, viscosity and surface tension were investigated during the storage conditions at three different temperatures (25, 40 and $60^{\circ}C$) over 90 days. No noticeable changes of color were observed when stored at 25 and $40^{\circ}C$. However, the color of white poloxamer gels turned yellow during storage at $60^{\circ}C$. The drug contents were unchanged during storage at $25^{\circ}C$ but had tendency to decrease at $40^{\circ}C$. The drug contents were highly decreased over 40-50% when stored at $60^{\circ}C$. The viscosity of a poloxamer-based gel was unchanged during storage at 25 and $40^{\circ}C$ but greatly increased at $60^{\circ}C$. The surface tension of a poloxamer-based gel was not changed at three different temperatures. The storage conditions of a poloxamer-based gel containing capsaicin analog can be considered for further clinical applications.

Keywords

References

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