한약재 수치에 관한 연구 (V) - 갈근의 수치전.후 Puerarin의 함량분석 및 시험관내에서 최종당화산물 생성억제 효능 -

Studies on the Processing of Herbal Medicines (V) -Quantitative Analysis of Puerarin and Inhibitory Effects on the Formation of Advanced Glycation Endproducts(AGEs) in Vitro of Unprocessed- and Processed Puerariae Radix-

Advanced glycation end products(AGEs) are largly involved in the pathogenesis of diabetic complications. It is obvious that inhibition of AGEs formation is important in preventing the occurrence and progression of diabetic complications. Therefore, to seek possible AGEs inhibitors in herbal medicines, unprocessed - und processed Puerariae Radix were tested. The inhibitory effect on AGEs formation was slightly increased through processing. Unprocessed-, processed Puerariae Radix and puerarin showed potential inhibitory action than that of positive control, amino guanidine HCI.