식물 추출물의 Pityrosporum ovale 및 Candida albicans에 대한 항진균 활성

Antifungal Activity of Plant Extracts against Pityrosporum ovale and Candida albicans

  • 유시용 (한국화학연구원 생명의학연구부) ;
  • 김성덕 (충남대학교 자연과학대학 생물학과) ;
  • 장소영 (충남대학교 자연과학대학 생물학과)
  • 발행 : 2003.12.30

초록

For the purpose of searching for the new antifungal agent from the plant origin, we have examined twenty seven species of medicinal plants for the antifungal activity against Candida albicans and Pityrosporum ovale. The whole MeOH extract of each plant material and the n-hexane and EtOAc fractions were evaluated individually for the antifungal activity. Among the test materials, the fractions from the root bark of Zanthoxylum schinifolium, Zanthoxylum piperitum and Citrus unshiu showed significant antifungal activities in a dose dependent manner against Pityrosporum ovale and Candida albicans, respectively.

키워드

참고문헌

  1. 정해영(1993) 천연 민간 생약으로부터 항암물질의 분리 동정 및 그 작용 기전에 관한 연구-천연물로부터 항암제 개발에 대한 연구보고서. pp. 53-58. 성균관대학 약학대학, 서울
  2. Peter, B. Kaufman, Leland, J. Cseke, Sara, Warber, James, A. Duke, and Harry, L. (1998) Natural products from plants, CRC Press (Boca Rato, Boston, London, New York, Washington, D.C.) 37-90
  3. Farnsworth, N. R. (1985) Medical plants in therapy. Bulletin of the World Health Organization. 63: 965-981
  4. Sternberg, S. (1994) The emersing fungal threat. Science, 266: 1632-1634 https://doi.org/10.1126/science.7702654
  5. Grayer, R. J. and Harbon, J. B. (1994) A survey of antifungal compounds from high plants. Phytochemistry, 37: 19-42 https://doi.org/10.1016/0031-9422(94)85005-4
  6. Borelli, D. (1980) Treatment of Pityriasis versicolor with ketoconazole. Reviews of Infentious Diseases, 4: 592
  7. Mattew, J. S., Omar, P. S., and Jerome, L. S. (1993) Systemic drugs in the treatment of dermatophytosis. Int. J. Dermatology, 32: 16-21 https://doi.org/10.1111/j.1365-4362.1993.tb00952.x
  8. 방규호(2000) 항진균성 trans-cinnamaldehyd의 작용기전 및 구조 활성. 충남대학교 약학대학 박사학위 논문 1-6
  9. Thouvenel, C., Gantier, J. C., Duret, P., Fourneau, C., Hocquemiller, R., Ferreira, M. E., Rojas de Arias A., and Fournet, A. (2003) Antifungal compounds from Zanthoxylum chiloperone var. angustifolium. Phytother. Res. 17(6): 678-680 https://doi.org/10.1002/ptr.1137
  10. Chaaib, F., Queiroz, E. F., Ndjoko, K., Diallo, D., and Hostettmann, K. (2003) Antifungal and antioxidant compounds from the root bark of Fagara zanthoxyloides. Planta Med. 69(4): 316-320 https://doi.org/10.1055/s-2003-38877
  11. Abreu, G. W., Weber, A. D., Giacomelli, S. R., Simionatto, E., Dessoy, E. C, and Morel, A. F. (2003) Composition and antibacterial activity of the essential oils from Zanthoxylum rhoifolium. Planta Med. 69(8): 773-775 https://doi.org/10.1055/s-2003-42783
  12. Chen, I. S., Tsai, I. L., Lin, W. Y., Teng, C. M., Ishikawa, T., Doong, S. L., Huang, M. W., and Chen, Y. C. (2000) Coumarins and Antiplatelet Constituents from the Root bark of Zanthoxylum schinifolium. Planta Medica. 66: 618-623 https://doi.org/10.1055/s-2000-8648
  13. Jo, Y. S., Huong, D. T. L., Bae, K. H., Lee, M. K., and Kim,Y. H. (2002)Monoamine oxidase inhibitory coumarin from Zanthoxylum schinifolium. Planta Med. 68(1): 84-85 https://doi.org/10.1055/s-2002-20056
  14. 최옥자(1994) 약초의 성분과 이용, 371. 일월서각, 서울
  15. 도동선, 이상명, 나민균, 배기환(2002) 충치원생세균 Streptococcus mutans OMZ 176에 대한 약용식물 추출물의 항균활성. Kor. J. Pharmacogn. 33(4): 319-323
  16. 김승권(1994) 최신병원미생물학, 75. 고문사, 서울
  17. Wei, P. H., Chen, L. R., Wei, Y. Q., Yuan, J. R., Ma, J. P., and Chen, L. X. (2002) Determination of alkaloids from Coptis chinensis Franch. and Phellodendron amurense Rupr. Decocted together in baitouweng decocta by high performance capillary electrophoresis. Se Pu. 20(6): 554-556
  18. Yoo, C. K. (1997) The recent trends in research of new antifungal agents. New Drug News, 5: 14-24