Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anti-tumor Effect of Korean Mistletoe Extract Intensified with Mistletoe Lectin against Melanoma Cells in vitro and in vivo

Lectin으로 강화한 한국산 겨우살이 추출물의 in vitro 및 in vivo에서의 피부암에 대한 항암효과

  • Published : 2003.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

The mistletoe lectins are major active components in the extrct of Viscum album var. coloratum. This study was performed to investigate the anti- skin cancer effect of Korean mistletoe extract intensified with mistletoe lectin (KI 2103S). B16F10 melanoma cells were allografted in C57BL/6 mice and F344 rats. The effect of KI 2103S on melanoma was measured by monitoring tumor index. The KI 2103S was injected intra-tumorally and tumor index was decreased in dose dependent manner.

Keywords

References

  1. 이영노(2003) 원색한국식물도감, 92-95,교학사,서울
  2. Fukunaga, T., Kajikawa, I., Nishiya, K., Watanabe, Y., and Takeya, K (1987) Studies on the constituents of the European mistletoe, Viscum album L. Chem. Pharm. Bull. 35: 3292 https://doi.org/10.1248/cpb.35.3292
  3. Lee, R. T., Gabius, H. J., and Lee, Y. C. (1992) Ligand binding characteristics of the major mistletoe lectin. J. BioI. Chem. 267: 2372
  4. Jordan, E. and Wagner, H. (1986) Structures and properties of polysaccharides from Viscum album. Oncology. 43 (Suppl 1), 8 https://doi.org/10.1159/000226414
  5. Khwajawa, T. A., Dias, D. B., and Pentecost, S. (1986) Recent studies on the anticancer activities of mistletoe and its alkaloids. Oncology. 43 (Suppl 1), 42 https://doi.org/10.1159/000226419
  6. 최상진,권학철,정애경,최상운,김경란,이선미,표석능,이강노 (2001) 상기생의 트라이테르펜 및 페놀성 성분, 약학회지 45(6): 591-598
  7. Park, W. B., Choung, B.Y., Park, S. M., Lee, T. S., Kim, J. H., and Ham, S. S. (1999) Antitumor activities of extracts and Lectin from Viscum album L. and Viscum album var. coloratum on cultured HL-60 cells, Food Sci. Biotechnol. 8(4): 232-237
  8. Lyu, S. Y, Park, S. M., Choung, B. Y, and Park, W. B. (2000) Comparative study of korean (Viscum album var. coloratum) and european mistletoe (Viscum album), Arch. Pharm. Res. 23(6): 592-598 https://doi.org/10.1007/BF02975247
  9. Lyu, S. Y., Park, W.B., Choi, K. H., and Kim, W.H. (2001) Involvement of caspase-3 in apoptosis induced by Viscum album var. coloratum agglutinin in HL-60 cells, Biosci. Biotechnol. Biochem. 65(3): 534-541 https://doi.org/10.1271/bbb.65.534
  10. Park, W. B., Choung, B. Y., Park, S. M., Kim, H. S., and Lyu, S. Y. (1999) Effects of drying of mistletoe on cytotoxicities against cultured HL-60 and Molt-4 cells, Food Sci. Biotechnol. 8(6): 391-396
  11. Park, W. B., Lyu, S. Y., Kim, J. H., Choi, S. H., Chung, H. K., Ahn, S. H., Hong, S. Y., Yoon, T. J., and Choi, M. J. (2001) Inhibition of tumor growth and metastasis by Korean mistletoe lectin is associated with apoptosis and antiangiogenesis, Cancer Biotherapy and Radiopharmaceuticals 16(5)
  12. Lyu, S. Y., Choi, S. H., and Park, W. B. (2002) Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p. 53, Arch. Pharm. Res. 25(1): 93-101 https://doi.org/10.1007/BF02975269
  13. Bussing, A. and Schietzel, M. (1999) Apoptosis-inducing properties of Viscum album L. extracts from different host trees, correlate with their content of toxic mistletoe lectins, Anticancer Research 19: 23-28
  14. 윤택준,유영춘,홍은경,조영호,이석원 (1994) I. Azuma, 유보림, 김종배, 마우스 Macrophage의 IL1 및 TNF-a의 분비유도에 있어서 한국산 겨우살이 추출물이 미치는 영향, 생약학회지 25(2): 132-139
  15. 강태봉, 윤택준, 김종배, 송성규, 이관희, 곽진환 (2001) 한국산 겨우살이로부터 정제된 렉틴성분 KML-IIU의 예비독성 및 일반약리시험, 약학회지 45(3): 251-257
  16. Bocci, V. (1993) Mistletoe (Viscum album) lectins as cytokine inducers and immunoadjuvant in tumor therapy. A review., J. Biol. Regul. Homeost. Agents. 7(1): 1-6
  17. Mannel, D. N., Becker, H., Gundt, A., Kist, A., and Franz, H. (1991) Induction of tumor necrosis factor expression by a lectin from Viscum album, Cancer Immunol Immunother 33(3): 177-82 https://doi.org/10.1007/BF01756139
  18. Zarkovic, N., Zatkovic, K., Grainca, S., Kissel, D., and Jurin, M. (1997) The Viscum album preparation Isorel inhibits the growth of melanoma B16F1O by influencing the tumor-host relationship, Anticancer Drugs S17-22
  19. Park, W. B., Ju, Y J., and Han, S. K. (1998) Isolation and characterization of $\beta$-galactoside specific lectin from Korean mistletoe (Viscum album var. coloratum) with lactose-BSAsepharose 4B and changes of lectin conformation, Arch. Pharm. Res. 21(4): 429-435 https://doi.org/10.1007/BF02974638
  20. 박원봉, 김희숙, 나혜복, 함승시(1995) 유산균 발효에 의한 겨우사리 중의 렉틴 성분의 변화 : pH, 온도의 영향, 당특이성, 림프구 자극분열효과, 약학회지 39(1): 24-30
  21. Park, W.B., Han, S. K., Lee, M. H., and Han, K. H. (1997) Isolation and characterization of lectins from stem and leaves of korean mistletoe (Viscum album var. coloratum) by affinity chromatography, Arch. Pharm. Res. 20(4): 306-312 https://doi.org/10.1007/BF02976191
  22. Lyu, S. Y, Rhim, J. Y, Moon, Y. S., Jung, S. H., Lee, K. Y., and Park, W. B. (2002) Antitumor activities of extract of Viscum album var. coloratum modified with Viscum album var. coloratum agglutinin, Natural Product Sciences 8(4):155-16