Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of Methanol Extract from Cornis fructus on Melanogenesis

산수유 메탄올 추출물이 B16/F10 Melanoma 세포주의 멜라닌 생성에 미치는 영향

  • Choi, Won-Young (Department of Herbal Resources Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jeong-Ho (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Baek, Seung-Hwa (Department of Herbal Resources Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Chun, Hyun-Ja (Division of Natural Science, Wonkwang University)
  • 최원형 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이정호 (원광대학교 제3의학과) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 천현자 (원광대학교 자연과학기술학부)
  • Published : 2003.03.30
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Abstract

Cornis fructus has been traditionally used for treating allergy, asthma, hepatitis, and chronic nephritis. It major chemical constituents have been saponins, phenolic acids and loganin. The main aim of the present study was to examine the effect of methanol extract from Cornis fructus on melanogenesis. Cell were cultured in the presence of methanol extracts from Cornis fructus for 48 h, and there were estimated total melanin content as a final product and activity of tyrosinase, a key enzyme, in melanogenesis. Methanol extract from Cornis fructus increased the melanin content and tyrosinase activity in a dose-dependent manner. Particularly, it was observed that only methanol extract $200\;{\mu}g/ml$ stimulated the melanin secretion in B16/F10 melanoma cells by 152% at 48 h treatment and the activity of tyrosinase was increased by 261% in the presence of same concentration.

Keywords

References

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