Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Comparative effects of Radix Polygalae and Rhizoma Acori Graminei on CT105-induced neuroblastoma cell lines

원지(遠志)와 석창포(石菖蒲)의 단독 및 혼합추출액이 CT105 로 유도된 신경세포암 세포주에 미치는 영향

  • Han, Won-Ju (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Hyung-Soo (Department of Diagnosic Radiology, Wonkwang University Gunpo Hospital) ;
  • Kim, Sang-Tae (JuAm of Research Institute Bioscience & Biotechnolo) ;
  • Kim, Tae-Heon (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lyu, Yeoung-Su (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Hyung-Won (Department of Oriental Neuropsychiatry Medicine, College of Oriental Medicine, Wonkwang University)
  • 한원주 (원광대학교 한의과대학 신경정신과교실) ;
  • 김형수 (원광대학교군포병원 진단방사선과) ;
  • 김상태 (지젠바이오/주암생명공학연구소) ;
  • 김태헌 (원광대학교 한의과대학 신경정신과교실) ;
  • 류영수 (원광대학교 한의과대학 신경정신과교실) ;
  • 강형원 (원광대학교 한의과대학 신경정신과교실)
  • Published : 2003.11.30
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Abstract

Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the future AD will be the largest problem in public health service. From old times, Much medicines have been used for treatment of dementia, but there is no medicine having obvious effect. AD is one of brain retrogression disease. So We studied on herbal medicine that have a relation of brain retrogression. From old times, In Oriental Medicine, Radix Polygalae and Rhizoma Acori Graminei have been used for disease in relation to brain retrogression. We studied of anti-Alzheimer effect on CT105-induced neuroblastoma cell lines by Radix Polygalae(RP) and Rhizoma Acori Graminei(RAG) water extract. As the result of this study, In RP and RAG group, the apoptosis in the nervous system is inhibited, the repair against the degeneration of Neuroblastoma cells by CT105 expression is induced. These results indicate that In RP and RAG, RAG possess the strongest in inhibitory effect of apoptosis in the nervous system and repair effect against the degeneration of Neuroblastoma cells by CT105 expression.

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