Journal of Korean Society for Clinical Pharmacology and Therapeutics (임상약리학회지)

Korean Society for Clinical Pharmacology and Therapeutics (대한임상약리학회)
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Comparative Study of S-Adenosylmethionine and Ibuprofen for Effectiveness and Safety in the Treatment Osteoarthritis of Knee

골관절염 치료효과 및 안전성에 있어 S-Adenosylmethionine과 Ibuprofen의 비교 연구

  • Kim, Dae-Sung (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Jung, Young-Ok (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Do, Ju-Ho (Department of Internal Medicine, Keimyung University School of Medicine) ;
  • Koh, Hyek-Jae (Department of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Baek, Seung-In (Department of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Kim, Ho-Youn (Department of Internal Medicine, The Catholic University of Korea, College of Medicine) ;
  • Lee, Sang-Heon (Department of Internal Medicine, The Catholic University of Korea, College of Medicine)
  • 김대성 (한림대학교 의과대학 내과학교실) ;
  • 정영옥 (한림대학교 의과대학 내과학교실) ;
  • 도주호 (계명대학교 의과대학 내과학교실) ;
  • 고혁재 (가톨릭 대학교 의과대학 내과학교실) ;
  • 백승인 (가톨릭 대학교 의과대학 내과학교실) ;
  • 김호연 (가톨릭 대학교 의과대학 내과학교실) ;
  • 이상헌 (가톨릭 대학교 의과대학 내과학교실)
  • Published : 2003.12.30

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Abstract

Objective : To compare the efficacy and safety of S-adenosyl-methionine (SAMe) and ibuprofen in the treatment of patients with knee osteoarthritis. Methods : Sixty patients with knee osteoarthritis (OA) were enrolled in this study. Patients received a daily oral dose of 1200mg of SAMe and 1200mg of ibuprofen for 4 weeks Treatment efficacy was evaluated with clinical parameters as Lequesne's functional index and visual analog scale (VAS) of pain. Adverse effects were monitored from patient interviews and blood sampling. Results: The treatment efficacy evaluated by clinical parameters was not different in both groups. Gastrointestinal adverse effects were more frequently observed in ibuprofen group than in SAMe. Conclusion : SAMe was equally effective to ibuprofen in efficacy and better tolerated in short term treatment of patients with knee OA.

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