대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제24권1호
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- Pages.134-143
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- 2003
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- 1226-9174(pISSN)
Apoptosis and Anti-proliferaction by Saussurea lappa and Pharbitis nil in AGS Human Gastric Cancer Cell Line
- Ko Seong-Gyu (Department of Internal Medicine, College of Oriental Medicine, Sangji University) ;
- Oh Hee-Rah (Department of Internal Medicine, College of Oriental Medicine, Sangji University) ;
- Lee Sun-Dong (Department of Preventive Medicine, College of Oriental Medicine, Sangji University) ;
- Hwang Gwi-Seo (Department of Preventive Medicine, Kyungwon University School of Oriental Medicine)
- 발행 : 2003.03.01
초록
Objectives : We performed this study to understand the molecular basis of the antitumor effect of Saussurea lappa, Pharbitis nil, Plantago asiatica and Taraxacum mongolicum, which have been used for cancer treatment in Korean traditional medicine. Design: We analyzed, the effect of these medicinal herbs on proliferation and apoptosis of tumor cells and its association with gene expression, We performed semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR) analysis of cell cycle- and apoptosis-related genes using a gastric cancer cell line AGS. Results : Cell counting assay and