The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of the Sungjuchunggan-tang(Xingjiuqinggan-tang) on alcoholic metabolism and alcoholic liver damages

주상(酒傷)에 응용되는 성주청간탕(醒酒淸肝湯)이 알코올대사 및 간장애에 미치는 영향

  • Park Seong-Kyu (Institute of Oriental Medicine, Kyunghee University) ;
  • Yoon Sang-Hyub (Institute of Oriental Medicine, Kyunghee University) ;
  • Ryu Bong-Ha (Institute of Oriental Medicine, Kyunghee University) ;
  • Ryu Ki-Won (Institute of Oriental Medicine, Kyunghee University) ;
  • Kim Jin-Sung (Institute of Oriental Medicine, Kyunghee University)
  • 박성규 (경희대학교 한의학연구소) ;
  • 윤상협 (경희대학교 한의학연구소) ;
  • 류봉하 (경희대학교 한의학연구소) ;
  • 류기원 (경희대학교 한의학연구소) ;
  • 김진성 (경희대학교 한의학연구소)
  • Published : 2003.03.01
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Abstract

Objectives : The aim of this study was to investigate effects of the Sungjuchunggan-tang(Xingjiuqinggan-tang), which has been used for alcoholic diseases in Oriental medicine, on alcoholic metabolism and alcoholic liver damage. Methods : We evaluated the activities of alcohol dehydrogenase(ADH)and aldehyde dehydrogenase(ALDH), and measured the levels of AST, ALT, glucose, triglyceride, HDL-cholesterol, LDL-cholesterol and phospholipid in serum of guinea pigs. Results and Conclusions : In this experiment, Sungjuchunggan-tang, Pharbitidis Semen and Puerariae Radix significantly suppressed the activity of ADH which is a precursor enzyme of acetaldehyde. Sungjuchunggan-tang and Pharbitidis Semen significantly suppressed the activity of ALDH, which is a catabolic enzyme, and increased its level. Due to alcohol consumption, level of ALT and AST were significantly reduced. These experimental results suggest that Sungjuchunggan-tang and Pharbitidis Semen inhibit the formation of acetaldehyde in the metabolism of alcohol, and affect the recovery of weakened liver functions caused by alcohol.

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