주타액선에서 발생한 선양낭세포암종의 방사선치료성적

Treatment Results for Adenoid Cystic Carcinoma of the Major Salivary Gland

  • 이상욱 (연세대학교 의과대학 방사선종양학교실) ;
  • 김귀언 (연세대학교 의과대학 방사선종양학교실) ;
  • 박정수 (연세대학교 의과대학 외과학교실) ;
  • 최은창 (연세대학교 의과대학 이비인후과학교실) ;
  • 이강규 (연세대학교 원주의과대학 방사선종양학교실) ;
  • 박원 (연세대학교 의과대학 방사선종양학교실) ;
  • 서창옥 (연세대학교 의과대학 방사선종양학교실)
  • Lee Sang-Wook (Departments of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center) ;
  • Kim Gwi-Eon (Departments of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center) ;
  • Park Cheong-Soo (Departments of Otolaryngology, Yonsei University College of Medicine, Yonsei Cancer Center) ;
  • Choi Eun-Chang (Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
  • Lee Kang-Kyoo (Department of Radiation Oncology, Yonsei University Wonju College of Medicine) ;
  • Park Won (Departments of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center) ;
  • Suh Chang-Ok (Departments of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center)
  • 발행 : 2002.11.01

초록

Purpose: This study was to investigate clinical feature of adenoid cystic carcinoma (ACC) in the major salivary gland. Materials and Methods: A retrospective analysis was undertaken for 23 patients with adenoid cystic carcinoma of the major salivary gland, who completed postoperative radiotherapy at the Yonsei Cancer Center, Yonsei University Hospital between May 1981 and December 1999. The male to female ratio was 1.1:1. Median age was 50. Follow up periods were 12-180 months with the median follow-up time of 59 months. Results: Parotid gland, submandibular gland and sublingual gland were 17, 5 and 1 respectively. Overall failure rate was 26%. Local failure was observed in two patients with parotid gland origin. Five cases showed distant failure. Overall and disease free survival rate were 68% and 72% respectively. Conclusion: Major pattern of failure was distant failure. Resection margin status had not prognostic significance. Postoperative radiation treatment is an effective to control in the adenoid cystic carcinoma of the major salivary gland.

키워드

참고문헌

  1. Myers EN, Suen JY : Cancer ofthe head and neck. In : Alvi A, Myers EN, Carrau RL. Malignant tumors ofthe salivary glands. 3rd ed. Philadelphia: Saunders, 1996 : 525-561
  2. Matsuba HM, Thawley SE, Simpson JR, et al : Adenoid cystic carcinoma ofmajor and minor salivary gland origin. Laryngoscope. 1984 ; 94 : 1316-1318
  3. Conley J, Dingman DL : Adenoid cystic carcinoma in the head and neck (cylindroma), Arch Otolaryngol. 1974 ; 100 : 81-90 https://doi.org/10.1001/archotol.1974.00780040087001
  4. Leatstedt SW, Gaeta JF, Sako K, et al : Adenoid cystic carcinoma of major and minor salivary glands. Am J Surg. 1971 ; 122 : 756-762 https://doi.org/10.1016/0002-9610(71)90440-5
  5. Maso MD, Lippi L : Adenoid cystic carcinoma of the head and neck: A clinical study of 37 cases. Laryngoscope. 1985 ; 95 : 177-181
  6. Busuttil A : Adenoid cystic carcinoma of the minor salivary glands J Laryngol Otol. 1977 ; 91 : 41-53
  7. Spiro RN, Huvos AG, Strong EW : Adenoid cystic carcinoma : Factors influencing survival. Am J Surg. 1979 ; 138 : 579-583 https://doi.org/10.1016/0002-9610(79)90423-9
  8. Perzin KH, Gullane P, Clarimont AC : Adenoid cystic carcinoma arising in salivary glands. A correlation of histologic features and clinical course. Cancer. 1978 ; 42 : 265-282 https://doi.org/10.1002/1097-0142(197807)42:1<265::AID-CNCR2820420141>3.0.CO;2-Z
  9. Marsh WL, Allen MS : Adenoid cystic carcinoma. Biologic behavior in 38 patients. Cancer. 1979 ; 43 : 1463-1473 https://doi.org/10.1002/1097-0142(197904)43:4<1463::AID-CNCR2820430437>3.0.CO;2-G
  10. Dick de Haan L, De Mulder PH, Vermorken JB, et al : Cisplatin based chemotherapy in advanced adenoid cystic carcinoma of the head and neck. Head Neck. 1992 ; 14 : 273-277 https://doi.org/10.1002/hed.2880140403
  11. Gates GA : Minor salivary gland tumors ofthe oral cavity. Otolaryngol Clin N Am. 1972 ; 5 : 283-289
  12. Howard DJ, Lund VJ : Reflections on the management of adenoid cystic carcinoma of the nasal cavity and paranasal sinuses. Otolarygol Head Neck. 1985 ; 93 : 338-341 https://doi.org/10.1177/019459988509300309
  13. Takagi D, Fukuda S, Furuta Y, et al : Clinical study of adenoid cystic carcinoma of the head and neck. Auris Nasus Laryx. 2001 ; 28: S99-S102 https://doi.org/10.1016/S0385-8146(01)00073-6
  14. American Joint Committee on Cancer: AlCC cancer staging manual 5th ed. philadelphia. Pa. Lippincott-Raven, 1997
  15. Carter RL, Tanner NSB, Clifford P, Shaw HJ : Perineural spread in squamous cell carcinomas of the head and neck : a clinicopathological study. Otolaryngology. 1979 ; 4 : 271-281 https://doi.org/10.1111/j.1365-2273.1979.tb01900.x
  16. Smout MS. Frenck AJ : Prognosis of pseudoadenomatous basal-cell carcinoma : cylindroma, adenocystic carcinoma. Arch Pathol. 1961 : 72 : 107-112
  17. Vrielinck LJG, Ostyn F. van Damme B, van den Bogaert W, Fossion E : The significance of perineural spread in adenoid cystic carcinoma of the major and minor salivary glands. Int J Oral Maxillofac Surg. 1988 : 17 : 190-193 https://doi.org/10.1016/S0901-5027(88)80030-4
  18. Smith LC, Lane N, Rankow RM : Cylindroma (adenoid cystic carcinoma). A report of fifty-eight cases. Am J Surg. 1965 ; 110 : 519-526 https://doi.org/10.1016/0002-9610(65)90030-9
  19. Szanto PA. Luna MA, Tortoledo ME, White RA : Histologic grading of adenoid cystic carcinoma of the salivary gland. Cancer. 1984 : 54 : 1062-1069 https://doi.org/10.1002/1097-0142(19840915)54:6<1062::AID-CNCR2820540622>3.0.CO;2-E
  20. Shintani S, Alcalde RE. Matsumra T, Terakado N : Extracellular matrices expression in invasion area of adenoid cystic carcinoma of salivary gland. Cancer Letters. 1997 ; 116 : 9-14 https://doi.org/10.1016/S0304-3835(97)04730-7
  21. Garden AS, Weber RS, Morrison WH, Ang KK, Peters LJ : The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation. Int J Radiat Oncol Biol Phys. 1995 ; 32 : 619-626 https://doi.org/10.1016/0360-3016(95)00122-F
  22. Yamamoto Y, Saka T, Makimoto K, et al : View from beneath : Pathology in focus. Histological changes during progression of adenoid cystic carcinoma. J Laryngol Otol. 1992 ; 106 : 1016-1020
  23. Beckhardt RN, Weber RS, Zane R, et al : Minor salivary gland tumors of the palate : Clinical and pathologic correlates of outcome. Larygoscope. 1995 ; 105 : 1155-1160 https://doi.org/10.1288/00005537-199511000-00003
  24. Matsuba HM, Simpson JR, Manuney M, et al : Adenoid cystic salivary gland carcinoma : A clinicopathologic correlation. Head Neck Surg. 1986 ; 8 : 200-204 https://doi.org/10.1002/hed.2890080312
  25. Nascimento AG, Amaral ALP, Prado AF, et al : Adenoid cystic carcinoma of salivary glands A study of 61 cases with clinicopathologic correlation. Cancer. 1986 ; 57 : 312-319 https://doi.org/10.1002/1097-0142(19860115)57:2<312::AID-CNCR2820570220>3.0.CO;2-A
  26. Spiro RH, Huvos AG : Stage means mare than grade in adenoid cystic carcinoma. Am J Surg. 1992 ; 164 : 623-628 https://doi.org/10.1016/S0002-9610(05)80721-4
  27. Ellis ER, Million RR, Mendenhall WM, et al : The use of radiation therapy in the management of minor salivary gland tumors. Int J Radiat Oncol Biol. Phys. 1987 ; 15 : 613-617
  28. Simpson JR, Thawley SE, Matsuba HM : Adenoid cystic salivary gland carcinoma : Treatment with irradiation and surgery. Radiology. 1984 ; 151 : 509-512 https://doi.org/10.1148/radiology.151.2.6324280
  29. Vikram B, Strong EW, Shah JP, et al : Radiation therapy in adenoid-cystic carcinoma. Int J Radiat Oncol Biol Phys. 1983 ; 10 : 221-223
  30. Prokopakis EP, Snyderman CH, Hanna EY, Carrau RL, Johnson JT, Amico FD : Risk factors for local recurrence of adenoid cystic carcinoma : The role of postoperative radiation thjerapy. Am J Otol. 1999 ; 20 : 281-286 https://doi.org/10.1016/S0196-0709(99)90028-5
  31. Haddad A, Enepekides DJ, Manolidis S, et al : Adenoid cystic carcinoma of the head and neck. A clinicopathologic study of 37 cases. J Otolaryngol. 1995 ; 24 : 201-205
  32. Horiuchi J, Shibuya H, Suzuki S, et al : The role of radiotherapy in the management of adenoid cystic carcinoma of the head and neck. Int J Radiat Oncol Bioi Phys. 1987 ; 13 : 1135-1141 https://doi.org/10.1016/0360-3016(87)90185-4