Clinical and Experimental Pediatrics
- Volume 45 Issue 5
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- Pages.629-636
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- 2002
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- 2713-4148(eISSN)
Characteristics of Seizures and Neuronal Nitric Oxide Synthase Expression of Hippocampus in Hyperthermia-Induced Seizures of Developing Rat
고체온으로 경련이 유발된 경우 경련의 양상과 쥐 해마부의 Neuronal Nitric Oxide Synthase 발현
- Kim, Doo-Kwun (Department of Pediatrics, Dongguk University College of Medicine) ;
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Jung, Dong-Keun
(Department of Physiology, Donga University College of Medicine)
- Received : 2001.11.06
- Accepted : 2002.02.05
- Published : 2002.05.15
Abstract
Purpose : Our study was aimed to investigate the characteristics of seizures as well as to determine whether the expression of neuronal nitric oxide synthase expression(nNOS) of hippocampus has an affect in the hyperthermic seizure in developing rat. Methods : Hyperthermic seizures were repeatedly induced twice a week for four weeks in 20-day old Spraque-Dowley rats. Fifty two rats were used as a hyperthermic group and 30 rats used as a normothermic control group. Hyperthermic seizures were induced in a water bath at
목 적 : 고체온에 의하여 유발된 반복성 열성경련에서 경련의 양상과 해마부의 nNOS 발현을 비교관찰하고 열성경련과 nNOS의 관계를 알아보기 위하여 연구를 시행하였다. 방 법 : 생후 20일된 Spraque-Dowley rat을 이용하여 1주일에 2회씩 4주간 모두 8회 온수에 노출시켜 고체온에 의한 반복적인 열성경련을 유발하였다. 실험에 이용된 쥐는 모두 82마리로서 이중 52마리는 실험군으로서 항온조에서 4분간