Clinical and Experimental Pediatrics
- 제45권10호
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- Pages.1219-1226
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- 2002
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- 2713-4148(eISSN)
2000-2001년 수도권 지역 홍역 유행의 양상
The Characteristics of the 2000-2001 Measles Epidemic in the Seoul Metropolitan Area
- 피대훈 (고려대학교 의과대학 소아과학교실) ;
- 변소훈 (고려대학교 의과대학 소아과학교실) ;
- 김경범 (관동대학교 의과대학 소아과학교실) ;
- 유영 (동부시립병원 소아과) ;
- 이기형 (고려대학교 의과대학 소아과학교실) ;
- 신영규 (고려대학교 의과대학 소아과학교실)
- Pee, Dae Hun (Department of Pediatrics, College of Medicine, Korea University) ;
- Byun, So Hoon (Department of Pediatrics, College of Medicine, Korea University) ;
- Kim, Kyung Burm (Department of Pediatrics, College of Medicine, Kwandong University) ;
- Yoo, Young (Department of Pediatrics, Seoul Dongbu Municipal Hospital) ;
- Lee, Kee Hyoung (Department of Pediatrics, College of Medicine, Korea University) ;
- Shin, Young Kyoo (Department of Pediatrics, College of Medicine, Korea University)
- 투고 : 2002.01.11
- 심사 : 2002.07.15
- 발행 : 2002.10.15
초록
목 적 : 국내에서는 1960년대 중반 이후 꾸준히 홍역 예방 접종을 시행해 옴에도 불구하고 2000-2001년에 전국적인 홍역의 대유행이 발생하였다. 저자들은 수도권 지역내 홍역 환아 중 입원 치료를 받은 환아를 대상으로 임상 양상의 특징을 조사하고 예방 접종의 효과에 대하여 알아보았다. 방 법: 2000년 6월부터 2001년 2월까지 고려대학교 안산병원, 관동대학교 일산 명지병원 및 서울 동부시립병원 소아과에서 임상적으로 진단된 홍역 환자 305명을 대상으로 연령과 성, 홍역 예방 접종력, 증상이 나타난 후 입원까지의 기간, 입원 기간, 합병증의 유무 및 그 유형 그리고 혈청 홍역 특이 IgM/IgG 항체를 검사하여 백신 실패율을 구하였다. 결 과 : 대상 환아 305명 중 12개월 미만은 118명(38.7%), 12-47개월은 84명(27.5%), 48개월 이상은 103명(33.8%)이었고 남녀비는 1.2 : 1로 남아가 많았다. 발병 연령은
Purpose : To assess the clinical characteristics of the 2000-2001 measles outbreak in the Seoul metropolitan area, Korea, the clinical data of measles inpatients were analyzed. Methods : Three hundred and five children diagnosed with measles by clinical manifestation from July, 2000 to February, 2001, in Seoul, Ilsan and Ansan City were grouped according to their age and investigated for clinical manifestations, vaccination history and measles-specific IgM/IgG antibody positivity. Results : Thirty eight point seven percent of the subjects were less than 12 months of age, 27.5 % were 12-47 months of age and 33.8% were 48 months of age or older. There was no significant sexual difference(male : female=1.2 : 1). This epidemic started in June, 2000 and the number of patients increased abruptly in October, peaked in December and finally decreased after February, 2001. It started from the older age group and moved to the younger. Sixty five point two percent had a history of more than 1-dose vaccination and 13.6% of the patients equal or more than 48 months of age had a history of 2-dose vaccination. Primary vaccine failure rate was 59.4%(107/180) and secondary vaccine failure rate was 3.9%(7/180) in 1 dose vaccinees. Sixty one point six percent showed more than one complication and 38.4% had no complication. The most common complication was pneumonia(31.8 %), followed by bronchitis(11.5%) and acute otitis media(4.6%). Vaccination and dose were not related significantly with the occurrence of complications. Conclusion : Compared with previous outbreaks in Korea, clinical features showed no specific change in the 2000-2001 measles epidemic. However, primary vaccine failure rate was so high that the second vaccination at four to six years of age must be emphasized in Korea.