Clinical and Experimental Pediatrics
- Volume 45 Issue 9
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- Pages.1075-1082
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- 2002
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- 2713-4148(eISSN)
Changes of Serum Fatty Acid and Carnitine Levels after Administration of L-carnitine in Rats
흰쥐에서 L-carnitine 투여 후에 혈청 지방산과 Carnitine의 농도 변화
- Lee, Jae Won (Department of Pediatrcs, College of Medicine, Ewha Womans University) ;
- Hong, Young Mi (Department of Pediatrcs, College of Medicine, Ewha Womans University)
- Received : 2002.03.23
- Accepted : 2002.07.09
- Published : 2002.09.15
Abstract
Purpose : Obesity is known to be associated with hypertension, dyslipidemia, and fatty liver and is thought to be associated with increased levels of free fatty acids. One of the strategies for decreasing free fatty acid levels is stimulation of hepatic lipid oxidation with L-carnitine. Carnitine is an essential cofactor for transport of long-chain fatty acid into mitochondria for oxidation. This study was designed to evaluate the changes of serum fatty acids and carnitine levels after exogenous injection of L-carnitine. Methods : Sprague Dawley rats were divided into two groups. Group A was control. Group B was given intraperitoneal injection with L-carnitine(200 mg/kg) daily for two weeks. Serum lipid (total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol) and fatty acid levels were analyzed on the first day of the first and second weeks after injection of L-carnitine. Total, free, and acyl carnitine levels also were performed by a enzymatic cycling techniques at the same day intervals. Results : There was no significant difference between the two groups in total cholesterol, HDL-cholesterol, LDL-cholesterol levels before and after the administration of L-carnitine. But triglyceride levels were significantly decreased at the first week in group B compared with group A. Among free fatty acids, linoleic acid showed significant decrement(A group :
목 적: L-carnitine은 carnitine acyltransferase 효소에 의해 장쇄(long chain)지방산을 세포질에서 미토콘드리아로 이동시킬 때 필요한 효소로 미토콘드리아 내로 이동된 장쇄 지방산은