IMMUNE NETWORK
- Volume 2 Issue 2
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- Pages.115-124
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- 2002
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Immunomodulating and Antitumor Activities of Exo-secretion from Phellinus linteus
상황버섯(Phellinus linteus) 자실체 분비물의 면역활성 및 항암효과
- Maeng, Eun-Ho (Korea Testing and Research Institute for Chemical Industry) ;
- Lee, Yun-Tai (Department of Microbiology, Dankook University) ;
- Cho, Kyu-Bong (Department of Clinical Pathology, Shinheung College) ;
- Hong, Seung-Hee (National Cancer Center)
- Published : 2002.06.30
Abstract
Background: The chemical characteristics of the exo-secretion from Phellinus linteus (referred to as exo-secretion) including the compositions of amino acids and monosaccharides were investigated. In addition, cytotoxicity of the exo-secretion on 5 tumor cell lines derived from human cancers and its antitumor activity against ascitic sarcoma-180 cells were examined. Methods: The antitumor activity of exo-secretion from Phellinus linteus was determined by measuring parameters including tumor weight, life span of mice, chemotatic activity of leukocytes, counts of immune cells, and activity of cytokines. Results: The exo-secretion from Phellinus linteus showed no direct cytotoxicity to the five tumor cell lines tested, but it had a strong antitumor activity against sarcoma-180 cells in ICR mice as measured by tumor weight and life span of mice. The exo-secretion stimulated the chemotaxis of leukocytes and production of immune cells and cytokines. Conclusion: These results suggest that the exo-secretion from Phellinus linteus do not act as a direct cytotoxic substance to cancer cells but as an immunomodulator.