IMMUNE NETWORK
- Volume 2 Issue 1
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- Pages.35-40
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- 2002
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Characterization of CTLA-4 Antigen Expression: Identification of Molecules Composing Intracellular CTLA-4 Multiprotein Complex
CTLA-4 항원의 활성 T 세포내 발현의 특성: 세포질내 단백복합체 구성분자의 동정
- Rhim, Dae-Cheol (Department of Microbiology, College of Medicine, Hanyang University) ;
- Chung, Yong-Hoon (Department of Microbiology, College of Medicine, Hanyang University)
- Published : 2002.03.31
Abstract
Background: CTLA-4 (Cytotoxic T Lymphocyte associated Antigen 4, CD152) has been known as a homologue of CD28, an accessory molecule providing a key costimulatory signal for successful antigen-driven activations of T lymphocyte. Most of biochemical and cell biological characteristics of the CD152 protein remain unknown while those of CD28 have been characterized in detail. Methods: In this study CD152 expression in both