IMMUNE NETWORK
- 제2권1호
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- Pages.19-24
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- 2002
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- 1598-2629(pISSN)
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- 2092-6685(eISSN)
Salvia miltiorrhiza Inhibits Tumor Cell Growth in Association with Rb Dephosphorylation through Up-regulation of p21 Via a p53-dependent Pathway
- Chung, Jin (Department of Microbiology, College of Dentistry, Pusan National University) ;
- Chang, Jae-Eun (Department of Microbiology, College of Dentistry, Pusan National University) ;
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Son, Yong-Hae
(Department of Microbiology and Immunology, College of Medicine, Pusan National University,) ;
- Park, Hae-Ruyn (Department of Oral Pathology, College of Dentistry, Pusan National University) ;
- Lim, Suk Hwan (Department of Pediatrics, Mokpo Catholic Hospital) ;
- Oh, Yang-Hyo (Department of Microbiology and Immunology, College of Medicine, Pusan National University,) ;
- Lee, Moo-Yeol (Department of Microbiology and Immunology, College of Medicine, Pusan National University,) ;
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Park, Yeong-Min
(Department of Microbiology and Immunology, College of Medicine, Pusan National University,)
- 발행 : 2002.03.31
초록
Background: Salvia miltiorrhiza (SM), a traditional oriental medicine, has been reported to have anti-tumor properties, but its exact mechanism remains to be elucidated. In this study, we investigated several of the molecular events that occur in human breast carcinoma MCF-7 cells and human pulmonary adenocarcinoma A549 cells. Methods: For this purpose, we evaluated the growth-inhibitory effect of SM in association with the expressions of p53, p21, cyclin D1, and pRb, which are known to be involved in cell cycle arrest. The extent of thymidine incorporation was also examined to assess G1/S phase cell cycle arrest in both cells by