The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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Effect of Skin Burn on the Activities of Free Radical Generating and Scavenging Enzymes in Rat Liver

피부화상이 간의 유해산소 생성계 및 해독계 효소 활성에 미치는 영향

  • Park, Rae-Jun (Dept. of Physical Therapy, Taegu University) ;
  • Kim, Han-Soo (Dept. of Occupational Therapy, Taegu Health College) ;
  • Bae, Ju-Han (Dept. of Occupational Therapy, Kyongbuk Science College) ;
  • Lee, Hyun-Kee (Dept. of Physical Therapy, Kyongbuk National University Hospital) ;
  • Choi, Jae-Won (Dept. of Physical Therapy, Kyungbuk College) ;
  • Lee, Dong-Ho (Graduate School of Public Health, Kyungsan University)
  • 박래준 (대구대학교 물리 치료학과) ;
  • 김한수 (대구보건대학 작업치료과) ;
  • 배주한 (경북과학대학 작업치료과) ;
  • 이현기 (경북대학교병원 물리치료실) ;
  • 최재원 (경북전문대학 물리치료과) ;
  • 이동호 (경산대학교 보건대학원)
  • Published : 2002.03.31
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Abstract

In order to investigate a pathogenesis of liver damage induced by skin burn, thermal injury was induced by scald burn on entirely dorsal surface in rats (total body surface area 30%) except for inhalated injury. At 5 and 24 h after scald burn, biochemical assay in skin tissue, serum and liver tissue were examined. The effects of burn injury on the levels of glutathione, lipid peroxide and on the activities of oxygen of histologic and ultrasound changes, measuring. the protein concentration in plasma, and counting the number of intravascular polymorphonuclear leukocytes. Post burn 24 h, the content of glutathione was decreased (47.50%), whereas that of lipid peroxide was increased (37.01%), and the activity of superoxide dismutase was diminished (p<0.001). Thus decreasing the capacity of oxygen free radical scavenging enzymes led to oxidative injury in skin tissue. In liver tissue, at 24 h after scald burn, both the content of glutathione and the activity of catalase were markedly decreased (p<0.01, p<0.05), thus the imbalance between free radical generating and scavenging capacities has been induced.

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