Fine Needle Aspiration Cytology of Malignant Myoepithelioma of the Salivary Gland - A Case Report -

악성 근상피종의 세침흡인 세포학적 소견 -1 예 보고-

  • Lee, Jae-Hwa (Department of Pathology, Kosin University College of Medicine) ;
  • Park, Jean-Kyung (Department of Pathology, Kosin University College of Medicine) ;
  • Hur, Bang (Department of Pathology, Kosin University College of Medicine)
  • 이재화 (고신대학교 의학부 병리학교실) ;
  • 박진경 (고신대학교 의학부 병리학교실) ;
  • 허방 (고신대학교 의학부 병리학교실)
  • Published : 2002.06.30

Abstract

Malignant myoepithelioma (myoepithelial carcinoma), is a very rare malignant epithelial accounting for less than 1% of all salivary gland tumors and has an intermediate malignant potential. We report a case of malignant myoepithelioma arising in the left parotid giand in a 54-year-old man, which was difficult to differentiate from pleomorphic adenoma and other malignant salivary gland neoplasms. Fine needle aspiration cytology of the parotid gland showed cellular smear, composed of overlapped sheets and clusters or individually scattered tumor cells without any acinic or ductal structures. The tumor cells were rather uniform, with distinct cell borders and moderate amount of cytoplasm. The eccentrically located nuclei were oval to round and pleomorphic and showed prominent nucleoli. A few clear cells were noted in the cellular aggregates Metachromatic matrix was seen between individual tumor cells in a lacelike fashion, resembling pleomorphic adenoma. According to the immunohistochemical staining, we recognized that the component cells are myoeplthelial in nature, showing reactivity for the S-100 protein, vimentin, and actin.

Keywords

References

  1. Nagano T, Sugano I, Ishida Y, et al.: Salivary gland malignant myoepithelioma. A clinicopathologic and immunohist-ochemical study of ten cases. Cancer 83:1292-1299, 1998
  2. Graadt Van Roggen JF, Baatenburg-DE Jong RJ, Verschuur HP, Balhuizen JC, Siootweg PJ, Van Krieken JHJM: Myoepithelial carcinoma (malignant myoepithelioma): First report of an occurrence in the maxillary sinus. Histopathology 32:239-241, 1998
  3. Bombi JA, Alos L, Rey MJ, Mallofre C: Myoepithelial carcinoma arising in a benign myoepithelioma: Immunohistochemical, ultrastructural, and flow-cytometrical study. Ultrastruct Pathol 20:145-154, 1996
  4. Sheldon WH: So-called mixed tumors of the salivary glands. Arch Pathol 35:1-20, 1943
  5. Seifert G, Sobin LH: The World Health Organization's histological classification of salivary gland tumors. A commentary on the second edition. Cancer 70:379-385, 1992
  6. Barnes, L, Appel BN, Perz H, EI-Attar AM: Myoepitheliomas of the head and neck: Case report and review. J Surg Oncol 28:21-28, 1985
  7. Stephen SS: Diagnositc Surgical Pathology. 3rd ed, Philadelphia, Lippincott Co. 1999, pp863-864
  8. Kuwabara H, Uda H, Miyabe K, Saito K, Shibanushi T: Malignant plasmacytoid myoepithelioma of the palate: Histological observations compared to benign predominant plasmacytoid myoepithelial cells in pleomorphic adenoma of the palate. Utrastruct Pathol 22: 153-160, 1998
  9. Kuwabara H. Kohno K. Kishida F, et al.: Imprint cytology of malignant plasmacytoid myoepithelioma of the palate. [Letter] Acta Cytol 42:440-443, 1998.
  10. Torlakovic E, Ames ED, Manivel JC, Stanley MW: Benign and malignant neoplasms of myoepithelial cells: Cytologic findings. Diagn Cytopathol 9:655-660, 1993
  11. Savera AT, Sloman A, Huvos AG, Klimstra DS: Myoepithelial carcinoma of the salivary glands. A clinicopathlogic study of 25 patients. Am J Surg Pathol 24:761-774, 2000
  12. Takeda Y: Malignant myoepithelima of minor salivary gland origin. Acta Pathol Jpn 42:518-522, 1992
  13. Singh R, Cawson RA: Malignant myoepithelial carcinoma (myoepithelioma) arising in a pleomorphic adenoma of the parotid gland: An immunohistochemical study and review of the literature. Oral Surg Oral Med Oral Pathol 66:65-70, 1988