The Korean Journal of Cytopathology (대한세포병리학회지)

The Korean Society for Cytopathology (대한세포병리학회)
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A Comparision of AutoCyte PREP with Matched Conventional Smear in Cervicovaginal Cytology

자궁경부 세포검사에서 기존 도말과 AutoCyte PREP의 비교

  • Jang, Jae-Jung (Departments of Pathology, Asan Medical Center, Ulsan University College of Medicine) ;
  • Kim, Jung-Sun (Departments of Pathology, Asan Medical Center, Ulsan University College of Medicine) ;
  • Cho, Kyung-Ja (Departments of Pathology, Asan Medical Center, Ulsan University College of Medicine) ;
  • Khang, Shin-Kwang (Departments of Pathology, Asan Medical Center, Ulsan University College of Medicine) ;
  • Nam, Joo-Hyun (Departments of Obsterics and Gynecology, Asan Medical Center, Ulsan University College of Medicine) ;
  • Gong, Gyung-Yub (Departments of Pathology, Asan Medical Center, Ulsan University College of Medicine)
  • 장재정 (울산대학교 의과대학 서울아산병원 진단병리과) ;
  • 김정선 (울산대학교 의과대학 서울아산병원 진단병리과) ;
  • 조경자 (울산대학교 의과대학 서울아산병원 진단병리과) ;
  • 강신광 (울산대학교 의과대학 서울아산병원 진단병리과) ;
  • 남주현 (울산대학교 의과대학 서울아산병원 산부인과) ;
  • 공경엽 (울산대학교 의과대학 서울아산병원 진단병리과)
  • Published : 2002.06.30
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Abstract

This study was designed to compare the performance of liquid-based preparation from the AutoCyte PREP with the conventional cervicovaginal smear in masked split-samples. In randomly selected 840 cases, the conventional smear was always prepared first, and the AutoCyte PREP used the resldual cells on the collecting device. Parallel AutoCyte PREP slides and matched conventional smears were screened in a blind fashion. All abnormals and 10% random normal cases were reviewed by two pathologists in a blind fashion. The Bethesda System was used for reporting the diagnosis and specimen adequacy. The diagnoses from the two methods were agreed exactly in 767(91.3%) of 840 cases. The AutoCyte PREP demonstrated a 25% overall improvement in the detection of squamous intraepithelial lesion(SIL). The ratio of ASCUS to SIL was decreased as 0.45 compared with 1.00 of conventional smear. The AutoCyte PREP produced excellent cellular preservation and superior sensitivity for detection of atypical cells as compared to the conventional smear. It makes us to be able to subclassify ASCUS into from WNL to HSIL. We thought that the AutoCyte PREP method might contribute to increase the detection rate of abnormal cells than conventional methods.

Keywords

References

  1. Devesa SS, Young JL, Brinton LA, et al. : Recent trends in cervix uteri cancer. Cancer 64:2184-2190, 1989
  2. Pretorius R, Semrad N, Watring W, et al : Presentation of cervical cancer. Gynecol Oncol 42:48-53, 1991
  3. Parkin DM : Cancer in developing countries. Cancer Surv 19-20:519-561, 1994
  4. Gay JD, Donaldson LD, Coellner JR : False-negative results in cervical cytologic studies. Acta Cytol 29:1043-1046, 1985
  5. Dodd LG, Sneige N, Villarreal Y, et al. : Quality-assurance study of simultaneously sampled, non-correlating cervical cytology and biopsies. Diagn Cytopathol 9:138-144, 1993
  6. Bishop JW : Comparison of the CytoRich$^R$ system with conventional cervical cytology: Preliminary data on 2,032 cases from a clinical trial site. Acta Cytol 41:15-23, 1997
  7. Geyer JW, Hancock F, Carrico C, Kirkpatrick M : Preliminary evaluation of Cytokich$^R$: An improved automated cytology preparation. Diagn Cytopaihol 9:417-422, 1993
  8. Howell LP, Davis RL, Belk TI, Agdigos R, Lowe J : The AutoCyte preparation system for gynecologic cytology. Acta Cytol 42:171-177, 1998
  9. Grohs HK, Zahniser OJ, Geyer JW : Standardization of specimen preparation through mono/thin layer technology. In : Grohs HK, Husain OAN : Automated Cervical Cancer Screening. New York, Igaku-Shoin, 1994, pp.176-85
  10. Park lA, Lee SN, Chae SW, Park KH, Kim JW, Lee HP : Comparing the accuracy of ThinPrep Pap tests and conventional papanicolaou smears on the basis of the histologic diagnosis: A clinical study of women with cervical abnormalities. Acta Cytol 45:525-531, 2001
  11. Bishop JW, Bigner SH, Colgan TJ, et al. : Multicenter masked evaluation of AutoCyte PREP thin layers with matched conventional smears: Including initial biopsy results. Acta Cytol 42:189-197, 1998
  12. Austin RM, Ramzy I : Increased detection of epithelial cell abnormalities by liquid based gynecologic cytology preparations : A review of accumulated data. Acta Cytol 42:178-184, 1998
  13. Vassilakos P, Saurel J, Rondez R : Direct-to-vial use of the AutoCyte PREP liquid-based preparation for cervical-vaginal specimens in three european laboratories. Acta Cytol 43:65-68, 1999
  14. Baandrup U, Bishop JW, Bonfglio TA, et al. : Sampling, sampling errors and specimen preparation. Acta Cytol 44:944-948, 2000
  15. Krieger PA, AcGoogan E, Vooijs GP, et al. : Quality Assurance/control issues. International academy of cytology task force summary. Diagnostic cytology towards the 21st century : An international expert conference and tutoriaL Acta Cytol 42:133-140, 1998