Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Analgesic Effect of Daebangpung-tang on a Rat Model of Adjuvant-induced Arthritis

Adjuvant에 의해 유발된 관절염 백서모델에 있어서 대방풍탕의 진통효과

  • Sung Byung Gon (Professional graduate school of oriental medicine, Wankwang University) ;
  • Park Young Il (Professional graduate school of oriental medicine, Wankwang University) ;
  • Kim Jae Ju (Professional graduate school of oriental medicine, Wankwang University) ;
  • Kim Mi Sun (Professional graduate school of oriental Medicine, Wankwang University) ;
  • Kim Nam Kwen (Kunpo Medical Hospital, College of Oriental Medicine, Wankwang University) ;
  • Lim Kyu Sang (Professional graduate school of oriental medicine, Wankwang University)
  • 성병곤 (원광대학교 한의학전문대학원) ;
  • 박영일 (원광대학교 한의학전문대학원) ;
  • 김재주 (원광대학교 한의학전문대학원) ;
  • 김미선 (원광대학교 한의학전문대학원) ;
  • 김남권 (원광대학교 군포한방병원) ;
  • 임규상 (원광대학교 한의학전문대학원)
  • Published : 2002.02.01
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Abstract

Daebangpung-tang(DBPT) is one of the prescriptions used for the treatment of rheumatoid arthritis(RA) in oriental medicine. The present study aimed to examine the analgesic effect of DBPT on a rat model of CFA-induced arthritis, which is not identical to human auto-immune arthritis although it does have many features in common with RA, and the relation between DBPT-induced analgesia and steroid hormones. CFA-induced arthritis rat model used to test the effect of DBPT was chronic pain model. After the induction of arthritis, rats subsequently showed a reduced stepping force of the affected limb for at least the next 18 days. The reduced stepping force of the limb was presumably due to a painful knee, since oral injection of indomethacin produced temporary improvement of weight bearing. DBPT dissolved in water was orally administrated. After the treatment, behavioral tests measuring stepping force were periodically conducted during the next 4 hours. DBPT produce significant improvement of stepping force of the hindlimb affected by the arthritis lasting at least 3 hours. The magnitude of this improvement was equivalent to that obtained after an oral injection of 3mg/kg of indomethacin and this improvement of stepping force was interpreted as an analgesic effect. The reduced stepping force was divided into three stages(10-30g, 30-50g, and 50-70g). All experiments was performed at 50-70g of stepping force, since both DBPT and indomethacin showed the most excellent analgesic effect at 50-70g of stepping force. DBPT produced the improvement of stepping force of the affected hindlimb in a dose-dependent manner and showed analgesic effect on neuropathic pain as well. DBPT-induced analgesic effect could not be blocked by systemic injection of steroid antagonist mifepristone. The present study suggest 1) that DBPT produces a potent analgesic effect on the chronic knee arthritis pain model in the rat and 2) that steroids system does not mediate DBPT-induced analgesia.

Keywords

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