Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Design of Ultrasonic Nebulizer for Inhalation Toxicology Study of Cadmium with Application of Engineering Methodology and Performance Evaluation with Light-Scattering Photometer

공학적 기법을 응용한 카드뮴의 흡입독성 연구를 위한 초음파 네뷸라이져의 설계 그리고 광산란 광도계를 이용한 성능평가

  • Jeung Jae Yeal (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Milton Donald K. (Department of Environmental and Occupational Health Program, School of Public Health, Harvard University) ;
  • Kim Tae Hyeung (Department of Environmental Engineering, Changwon National University) ;
  • Lee Jong Young (Department of Preventive Medicine, School of Medicine, Kyungpook National University) ;
  • Chong Myoung Soo (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Ko Kwang Jae (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim Sang Duck (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang Sung Ho (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Song Young Sun (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Ki Nam (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 정재열 (원광대학교 한의학전문대학원 제3의학과) ;
  • 도날드밀턴 (하버드대학교 대학원 환경 및 산업보건학과) ;
  • 김태형 (창원대학교 환경공학과) ;
  • 이종영 (경북대학교 의과대학 예방의학교실) ;
  • 정명수 (원광대학교 한의학전문대학원 제3의학과) ;
  • 고광재 (원광대학교 한의학전문대학원 제3의학과) ;
  • 김상덕 (원광대학교 한의학전문대학원 제3의학과) ;
  • 강성호 (원광대학교 한의학전문대학원 제3의학과) ;
  • 송용선 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이기남 (원광대학교 한의학전문대학원 제3의학과)
  • Published : 2002.06.01
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Abstract

Author applied several engineering methodologies to classical ultrasonic nebulizer to cope with it's demerits. After several trials and errors, we got the several meaningful results. To evaluate the modified ultrasonic nebulizer for inhalation toxicology of cadmium, author used light-scattering photometer. This paper is the one part of inhalation exposure systems for inhalation toxicology study of cadmium. According to the testing conditions, source temperature 50℃ and inlet-duct band temperature 150℃, aerosol generation results for sodium chloride and cadmium chloride were as followings: Coefficients of variation(CV) of sodium chloride and cadmium chloride for repeated trials were 3.38 and 4.77 for 10g, 2.47 and 5.02 for 5g, and 4.70 and 2.98 for 2.5g. All the CVs were within 10% of acceptance variability. Count Per Minute(CPM) changes of NaCl and CdCl₂ for 5 repeated trials were similar. CPM ratios of CdCl₂/NaCl were 1.13 for 10g, 0.76 for 5g, and 1.06 for 2.5g. Relative aerosol generation of cadmium chloride to sodium chloride was the highest in 10g. Efficiency increases of 24.50% for 5g NaCl, 14.91 % for 2.5g NaCl, and 16.48% for 2.5g CdCl₂ with respect to theoretical efficiency were observed but 0.04% efficiency decrease was observed in 5g CdC₂. According to the modifications of source temperature(20, 50, 70℃) and inlet-duct band temperature(20, 50, 100, 150, 200℃), aerosol generation results for NaCl and CdCl₂ were as followings: CPM trends for each quantity excepting 10g NaCl in inlet-duct band temperature 200℃ were similar, and the highest CPM was observed in source temperature 70℃ to each inlet-duct band temperature. The highest CPMs to 10, 5, and 2.5g NaCl were observed in source temperature 70℃ and inlet-duct band temperature 20℃. Aerosol generation of cadmium chloride was increased with the higher source temperature, excepting inlet-duct band temperature 200℃. The highest CPMs for 10, 5, and 2.5g CdCl₂ were observed in source temperature 70℃ and inlet-duct band temperature 20℃, and this trend was similar to NaCl aerosol generation The highest CPMs for 10, 5, and 2.5g CdCl₂ were observed in source temperature 70℃ and inlet-duct band temperature 20℃, and this result was similar to NaCl aerosol generation. Observed efficiencies of 5 and 2.5g NaCl were similar to ifs theoretical efficiency but -3.08% efficiency decrease of 5g CdCl₂, 17.47% efficiency increase of 2.5g CdCl₂ were observed. CPM ratio of CdCl₂/NaCl of 10g was different to 5 and 2.5g, and 2.5g ratio was higher than 5g ratio. In conclusion, to get maximum aerosol generation for NaCl and CdCl₂ will be the conditions that set the appropriate inlet-duct band temperature for each materials and increase the source temperature. Sodium chloride can be used to evaluate the performance and predict the concentration for cadmium aerosol in aerosol generator and inhalation exposure system.

Keywords

References

  1. Goodman and Gilman's The Pharmacological Basis of Therapeutics(7th Ed.) Gilman, A.G.;Goodman, L.S.;Rall, T.W.;Murad, F.
  2. Toxicology of Metals Chang, L.W.
  3. Cadmium, Environmental Health Criteria 134. Int. Prog., Chemical Safety WHO
  4. Biological Monitoring of Toxic Metals Biological Monitoring of Cadmium Nordberg, G.F.;Nordberg, M.;T.W. Clarkson(et al.)(Eds.)
  5. Handbook on Aerosols Aerosol Generation Corn, M.;Esmen, N.A.;R. Dennis(Ed.)
  6. Aerosol Technology in Hazard Evaluation Mercer, T.T.
  7. Fine Particles Liu, B.Y.H.(Eds.)
  8. Aerosol Measurement Willeke, K.;Baron, P.A.
  9. J. scient. Instrum. v.27 A New Dust-Feed Mechanism Wright, B.M.
  10. Am Ind. Hyg. Ass. J. v.39 A Dust Generator for Laboratory Use Marple, V.A.;Liu, B.H.Y.;Rubow, K.L.
  11. Generation of Aerosols and Facilities for Exposure Experiments Willeke, K.
  12. Industrial Ventilation; A Manual of Recommended Practice(18th Ed.) ACGIH;Lansing, MI.
  13. Air Sampling Instruments for Evaluation of Atmospheric Contaminants(7th Edition) Hering, S.V.
  14. Comprehensive Toxicology: Toxicological Testing and Evaluation Sipes, G.;McQueen, C.A.;Gandolfi, A.J.
  15. STP Pharma Sci. v.4 Assessment of aerosol delivery systems for recombinant human deoxyribonuclease Cipolla, D.C.;Clark, A.R.;Chan, H.K.;Gonda, I.;Shiir, S.J.
  16. Pharm. Res. v.12 Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers McCallion, O.N.M;Taylor, K.M.G.;Thomas, M.;Taylor, A. J.
  17. Arch Int. Med. v.131 Production and characterization of aerosols Mercer T.T
  18. Chest v.80 Production of therapeutic aerosols; principles and techniques Mercer T.T.
  19. Aerosols and the lung: clinical and experimental aspects Therapeutic aerosols Newman S.P.;Charke S;Demetri P(eds.)
  20. 동의생리병리학회지 v.16 no.2 납의 흡입독성 연구를 위한 에어로졸 발생장치의 고안 및 실시간 모니터링을 이용한 성능평가 정재열;김정만;김태형;정명수;고광재;김상덕;강성호;송용선;이기남
  21. 동의생리병리학회지 v.16 no.1 시엽 추출물이 카드뮴에 흡입폭로된 랫드의 독성에 미치는 영향 강성호;천병렬;김상덕;송용선;이기남;정재열
  22. Appl. Phys. Lett. v.51 Chen, Y.L.;Brock, J.R.;Trachtenberg, I.
  23. Aerosol Sci. and Technol. v.12 Chen, Y.L.;Brock, J.R.;Trachtenberg, I.
  24. Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles Hinds, W.C.
  25. Toxicology Principles and Applications Niesink, R.J.M.;Vries, J. de;Hollinger, M.A.
  26. Inhalation Studies : Foundations and Techniques Phalen, R. F.
  27. Concepts in Inhalation Toxicology McClellan, R. O.;Henderson, R. F.