Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Acupuncture and Coptidis Rhizoma on Repeated Nicotine-induced Behavioral Sensitization in the rats

니코틴중독에 대한 족삼리 전침자극 및 황련의 작용기전

  • Chae Yun Byung (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee Born Bi (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kwon Young Kyu (Department of Physiology, College of Oriental Medicine, Kyungsan University) ;
  • Hahm Dae Hyun (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Shim In Sub (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Lee Hye Jung (Graduate School of East-West Medical Science, Kyunghee University)
  • 채윤병 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 이봄비 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 권영규 (경산대학교 한의과대학 생리학교실) ;
  • 함대현 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 심인섭 (경희대학교 동서의학대학원 침구경락학교실) ;
  • 이혜정 (경희대학교 동서의학대학원 침구경락학교실)
  • Published : 2002.08.01
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Abstract

We have previously demonstrated that repeated injections of nicotine produced an increase in locomotor activity, dopamine(DA), release and c-Fos expression in the nucleus accumbens, one of the major projection areas of the central DA system. Acupuncture as a therapeutic intervention is widely used for the treatment of many functional disorders such as substance abuse and mental dysfunction. And many studies have shown that Coptidis Rhizoma has a suppressive effect on the central nervous system (CNS) and can affect the neurotransmitter systems in the CNS. In order to investigate whether acupuncture and Coptidis Rhizoma have an influence on nicotine-induced reinforcing and behavioral effects, we examined the effect of zusanli(ST36) and Coptidis Rhizoma on repeated nicotine-induced locomotor activity, and zusanli(ST36) on c-Fos expression as an important maker of postsynaptic neuronal activity in nucleus accumbens. Male SD rats received Coptidis Rhizoma (100mg/kg, p.o.) 30 min before injections of nicotine (0.4 mg/kg, s.c.) for 7 days. Rats were followed withdrawal for 3 days and one challenge for 1 day. Systemic challenge with nicotine produced a much larger increase in locomotor activity. Pretreatment with acupuncture at zusanli(ST36, 100Hz) and Coptidis Rhizoma decreased in nicotine-induced locomotor activity. These results demonstrated that reduction in locomotor activity by acupuncture at zusanli(ST36, 100Hz) and Coptidis Rhizoma may be mediated by reduction of dopamine release. Our results suggest that acupuncture at zusanli(ST36, 100Hz) and Coptidis Rhizoma may have therapeutic effect on nicotine addiction.

Keywords

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