Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

The Effects of Jihwangyeumja and GamiJihwangyeumja water extract on The Cultured Primary Hippocampal Cell Damaged by XO/HX

지황음자와 가미지황음자 유출액이 XO/HX로 손상된 배양 해마신경세포에 미치는 효과

  • Lee Yong Geun (Department of Oriental Neuropsychiatry Medicine. College of Oriental Medicine, Wonkwang University) ;
  • Kim Sang Ho (Department of Oriental Neuropsychiatry Medicine. College of Oriental Medicine, Wonkwang University) ;
  • Min Sang Jun (Department of Oriental Neuropsychiatry Medicine. College of Oriental Medicine, Wonkwang University) ;
  • Yang Hee Suk (Department of Oriental Neuropsychiatry Medicine. College of Oriental Medicine, Wonkwang University) ;
  • Jang Hyun Ho (Department of Oriental Neuropsychiatry Medicine. College of Oriental Medicine, Wonkwang University) ;
  • Kim Tae Hean (Department of Oriental Neuropsychiatry Medicine. College of Oriental Medicine, Wonkwang University) ;
  • Kang Hyung Won (Department of Oriental Neuropsychiatry Medicine. College of Oriental Medicine, Wonkwang University) ;
  • Lyu Yeoung Su (Department of Oriental Neuropsychiatry Medicine. College of Oriental Medicine, Wonkwang University)
  • 이용근 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 김상호 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 민상준 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 양희숙 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 장현호 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 김태헌 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 강형원 (원광대학교 한의과대학 한방신경정신과학교실) ;
  • 유영수 (원광대학교 한의과대학 한방신경정신과학교실)
  • Published : 2002.10.01
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Abstract

The purpose of this study is to examine the toxic effects caused by xanthine oxidase/hypoxanthine(XO/HX) and the effects of herbal extracts such as JHYJ and GJHYJ on the treatment of the toxic effects. For this purpose, experiments with the cultured hippocampal cells from new born mice were done. The results of these experiments were as follows. 1. XO/HX, a oxygen radical-generating system, decreased the survival rates of the cultured cells on XTT assay and INT assay, the amount of DNA syntheses, and the amount of neurofilaments, and increased the lipid peroxidation. 2. JHYJ and GJHYJ have the efficacy of increasing the survival rates of the cultured cells. 3. JHYJ and GJHYJ have the efficacy of increasing the amount of neurofilaments and of decreasing the lipid peroxidation. 4. JHYJ and GJHYJ have the efficacy of increasing the amount of DNA syntheses. From the above results, it is suggested that Jihwangyeumja and Gamijihwangyeumja have marked efficacy as a treatment for the damages caused by the XO/HX-mediated oxidative stress. And Jihwangyeumja and Gamijihwangyeumja are thought to have certain pharmacological effects. Further dinical study of this pharmacological effects of Jihwangyeumja and Gamijihwangyeumja should be complemented.

Keywords

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