Childhood Kidney Diseases
- Volume 6 Issue 2
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- Pages.142-154
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- 2002
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- 2384-0242(pISSN)
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- 2384-0250(eISSN)
Expression of Osteopontin and Transforming Growth Factor- ${\beta}$ in Childhood Minimal Change Nephrotic Syndrome After Cyclosporine Treatment
미세변화 신증후군 환아에서 사이클로스포린 치료 후 Osteopontin과 Transforming Growth Factor-${\beta}$ 의 발현
- Lim Beom-Jin (Dept. of Pathology, Yonsei University, College of Medicine) ;
- Kim Pyung-Kil (Dept. of Pediatrics, Yonsei University, College of Medicine) ;
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Hong Soon-Won
(Dept. of Pathology, Yonsei University, College of Medicine) ;
- Jeong Hyeon-Joo (Dept. of Pathology, Yonsei University, College of Medicine)
- Published : 2002.10.01
Abstract
Purpose : One of the most important adverse effects of long-term cyclosporine therapy is nephrotoxicity, the morphologic changes of which include interstitial fibrosis and arteriolar hyalinization. Recently, several authors have shown that osteopontin plays an important role in the development of interstitial fibrosis by acting as a macrophage chemoattractant and stimulating the production of
목적 : 사이클로스포린(cyclosporine)은 효과적인 면역 억제제로서 현재에는 장기 이식 후 뿐 아니라 다양한 자가면역성 질병에서 그 사용 범위를 넓히고 있다. 신독성은 사이클로스포린의 대표적인 부작용으로서 그 특징적인 조직학적 소견은 간질의 섬유화와 세 동맥의 초자양 변화이다. 간질 섬유화에는 전통적으로