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경제동물의 주요 경제형질에 대한 표지인자를 이용한 선발(MAS)의 효율성

Efficiency of Marker Assisted Selection(MAS) over The Phenotypic Selection for Economic Traits in Economic Animals

  • 전광주 (한경대학교 생명공학과, 유전정보연구소)
  • Jeon, Gwang-Joo (Department of Genomic Engineering, Genomic Informatics Center, Hankyong National University)
  • 발행 : 2002.12.31

초록

유전표지인자를 이용한 선발(marker assisted selection; MAS)과 전통적인 표현형기록에 근거한 반응의 비교분석을 위하여 고정효과모델(deterministic model)을 이용하여 시뮬레이션을 하였다. 자신의 단일 기록을 이용한 경우와 자신의 기록과 자신의 표지인자 정보를 이용할 경우 유전력이 높을수록 MAS의 효율성이 38%정도 높게 나타났다. 그러나 유전력이 높은 경우(50%) MAS의 효율성은 약 1%정도로서 효율성이 대단히 낮은 것으로 나타났다. 자신의 기록과 부모의 표현형 정보에 표지인자 정보를 추가할 경우 MAS의 효율성은 27% 정도였으며 마찬가지로 유전력이 높은 경우에는 효율성이 0에 가깝게 나타났다. MAS의 효율성은 유전력이 낮을수록 그리고 이용한 표지인자의 유전적 변이가 클수록 효율성이 높아지는 것으로 나타났다.

The efficiency of marker assisted selection(MAS) over conventional selection index based sorely on phenotypic records was studied by deterministic simulation model. Parameter combination of heritability and amount of genetic variation due to the markers included in the index was employed. For the index with own phenotypic information vs. the index with own phenotypic plus marker information, the relative efficiency of MAS over the selection with phenotypic records was about 38% high when heritability was low(0.05). However, when heritability was high(50%), the relative efficiency of MAS was vary low and almost negligible. For more practical situation of selection index which included information on own, sire and dam, MAS was less effective than when selection criteria was only on own performance.

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참고문헌

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