Journal of Korean Physical Therapy Science (대한물리치료과학회지)

Korean Physical Therapy Science (대한물리치료과학회)
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The Effect of Continuous Ultrasound Therapy and Pulsed Ultrasound Therapy on Adjuvant Induced Rheumatoid Arthritis in Rat

지속적인 초음파치료와 맥동 초음파치료가 Adjuvant로 유도된 흰쥐의 관절염에 미치는 효과

  • Lee, Byeung-Ok (Dept. of Rehabilitation Medicine, Chungbuk Nat'l University Hospital) ;
  • Min, Kyung-Ok (Dept. of Physical Therapy, Young-in University) ;
  • Hong, Wan-Seng (Dept of Physical Therapy, Dongnam Health College) ;
  • Lee, Kyung-Moo (Dept. of Rehabilitation Medicine, Chungbuk Nat'l University Hospital) ;
  • Hwang, Seock-Yeon (Dept. of Clinical Pathology, Chungbuk Nat'l University Hospital)
  • 이병옥 (충북대학교병원 재활의학과) ;
  • 민경옥 (용인대학교 물리치료학과) ;
  • 홍완성 (동남보건대학 물리치료과) ;
  • 이경무 (충북대학교병원 재활의학과) ;
  • 황석연 (충북대학교병원 임상병리과)
  • Published : 2002.11.29
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Abstract

The drug therapy for rheumatoid arthritis must be maintained constantly or for the whole life but is apt to induce the adverse effects in gastrointestinal or renal system. Therefor, newer methods are paid attention to reduce adverse effects. The thirty-two rat female separated into seven groups depending on the therapy or Freund's adjuvant applied: Normal group(n=8) not received anything, Positive control group(n=8) only received adjuvant, USC group(n=8) received continuous US, USP group(n=8) received pulsed US. The physical and radiological findings by thermal and non-thermal effects of ultrasound were evaluated in groups with continuous mode at 1 MHz, $0.5\;W/cm^2$ for 6 minutes and with pulsed mode (duty cycle 1:9) at 1 MHz, $0.5\;W/cm^2$ for 6 minutes. The result summarized followings. 1. Swelling of forepaw and hindpaw was significantly reduced in USP. 2. Arthritis indices in USP group were significantly reduced than those in PCG. 3. In naked eye and radiologic findings, swelling was significantly prevented in USP group but not in PCG. The change of swelling, arthritis index, gross feature in naked eye, radiologic finding were significantly improved in all groups except for USC group, taking care for using its continuous mode.

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