The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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Effect of Ginseng Saponins on Nicotine-Induced Dopamine Release in the Rat Nucleus Accumbens and Striatum

인삼 사포닌이 흰쥐 측핵과 선조체에서 니코틴에 의한 도파민 유리에 미치는 효과

  • Kim, Sang-Eun (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Shim, In-Sop (Graduate School of EAst-West Medical Science, Kyung Hee University) ;
  • Chung, June-Key (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
  • Lee, Myung-Chul (Department of Nuclear Medicine, Seoul National University College of Medicine)
  • 김상은 (성균관대학교 의과대학 삼성서울병원 핵의학과) ;
  • 심인섭 (경희대학교 동서의학대학원) ;
  • 정준기 (서울대학교 의과대학 핵의학교실) ;
  • 이명철 (서울대학교 의과대학 핵의학교실)
  • Published : 2002.10.30
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Abstract

Purpose and Methods: We investigated the effect of ginseng total saponin (GTS) on nicotine-induced dopamine (DA) release in the striatum and nucleus accumbens of freely moving rats using in vivo microdialysis technique. Results: Systemic pretreatment with GTS decreased striatal DA release induced by local infusion of nicotine into the striatum. However, GTS had no effect on the resting levels of extracellular DA in the striatum. GTS also blocked nicotine-induced DA release in the nucleus accumbens. Conclusion: The results of the present study suggest that GTS acts on the DA terminals to prevent DA release induced by nicotine. This may reflect the blocking effect of GTS on behavioral hyperactivity induced by psychostimulants.

Keywords

References

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