The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

Effect of Electroacupuncture of GB30 on the Expression of c-Fos following Transient Forebrain Ischemia in Rats

환도 (GB30) 전침자극이 일과성 전뇌 허혈로 유발된 c-Fos 단백질 발현에 미치는 영향

  • 김재효 (원광대학교 한의과대학 경혈학교실) ;
  • 김풍식 (원광대학교 한의과대학 경혈학교실) ;
  • 김경식 (원광대학교 한의과대학 경혈학교실) ;
  • 김민선 (원광대학교 의과대학 생리학교실) ;
  • 박병립 (원광대학교 의과대학 생리학교실) ;
  • 손인철 (원광대학교 한의과대학 경혈학교실)
  • Published : 2002.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : Acupuncture and herbal medicine have been used to prevent and treat cerebrovascular accident, such as stroke, and many studies of acupuncture and moxibustion concerning stroke have been undertaken in humans and various animals. However, the protective effect of the electroacupuncture (EA) of Huan-do (GB30) on the transient forebrain ischemia injury has not been published. Methods : The nenroprotective effects of EA (2 ms, 10 Hz, and 1 - 2 mA) of GB30 on the transient forebrain ischemia injury were investigated by immunohistochemistry of c-Fos-like protein in Sprague-Dawley rats. Results : The transient forebrain ischemia injury resulted in increased expression of c-Fos-like protein (cFL) in the dentate gyms (DG) and CAl for 6 hrs after ischemia, and EA increased significantly expression of cFL in the CAl and DG. For 48 hrs after, there was delayed expression of cFL at the CAl and DG, representing the sign of neuronal cell death, but EA decreased the delayed expression of cFL, significantly. Conclusion : These results suggest that the nenroprotective effects of EA on transient forebrain ischemia injury may be related to excitatory regulation of cFL at the early stage and inhibitory regulation in the long term.

Keywords

References

  1. 수穴學(供鍼灸學專業用) 羅永芬(主編)
  2. Ann Clin Res v.12 no.6 Outcome of stroke in the Espoo-Kauniainen area Waltimo O;Kaste M;Aho K;Kotila M
  3. 임상중풍학 김영석
  4. 東醫寶鑑 許浚
  5. 實用中風防治手冊 常靑
  6. Stroke v.19 The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of collateral circulation Pulsinelli WA;Buchan AM
  7. J Neurol Sci v.179 Brain ischemia and reperfusion: molecular mechanisms of neuronal injury White BC;Sullivan JM;DeGracia DJ;O'Neil BJ;Neumar RW;Grossman LI;Rafols JA;Krause GS
  8. Prog Neurobiol v.62 Mechanisms underlying hypoxia-induced neuronal apoptosis Banasiak KJ;Xia Y;Haddad GG
  9. Nature v.311 no.5985 Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene Greenberg ME;Ziff EB
  10. Annu Rev Neurosci v.14 Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun Morgan JI;Curran T
  11. Stroke v.21 70-kDa heat shock protein and c-fos gene expression after transient ischemia Nowak TS;Ikeda J;Nakajima T
  12. Eur J Neurosci. v.77 Biphasic expression of the Fos and Jun families of transcription factors following transient forebrain ischaemia in the rat. Effect of hypothermia Kamme F;Campbell K;Wieloch T
  13. Stroke v.27 Immediate early gene expression in response to cerebral ischemia; Friend or Foe? Paul T. Akins;Philip K. Liu;Chung Y. Hsu
  14. 經穴治病明理 王富春(洪杰)
  15. Stroke v.20 Rodent Model of Cerebral Ischemia Ginsberg MD;Busto R
  16. Ann Neurol v.11 Temporal profile of neuronal damage in a model of transient forebrain ischemia Pulsinelli WA;Brierly JB;Plum F
  17. 경희대학원 박사학위 흰쥐의 前腦 虛血 모델에 對한 黃芩의 神經防禦效果 이병철
  18. 경희대학원 박사학위논문 흰쥐의 前腦 虛血 모델에 對한 釣鉤藤의 神經防禦效果 이인환
  19. Brain Res. Bull. v.53 Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury Hong JT;Ryu SR;Kim HJ;Lee JK(et al)
  20. Neurological Res v.23 Influence of acupuncture upon expressing levels of basic fibroblast growth factor in rat brain following focal cerebral ischemia-evaluated by time-resolved fluorescence immunoassay Ou YW;Han L;Da CD;Huang YL;Cheng JS
  21. Neurosci Lett. v.297 no.1 Acupuncture increases cell proliferation in dentate gyrus after transient global ischemia in gerbils Kim EH;Kim YJ;Lee HJ;Huh Y;Chung JH;Seo JC;Kang JE;Lee HJ;Yim SV;Kim CJ
  22. Acupunct Electrother Res v.25 no.2 Electro-acupuncture attenuates nitric oxide release from rat striatum after transient middle cerebral artery occlusion Zhao P;Huang ZN;Chen G;Cheng JS
  23. Acupunct Electrother Res. v.25 no.2 Regulation of glial cell line-derived neurotrophic factor expression by electroacupuncture after transient focal cerebral ischemia Wei G;Huang Y;Wu G;Cao X
  24. Acupunct Electrother Res. v.24 no.1 Electroacupuncture reduces rat's neuronal ischemic injury and enhances the expression of basic fibroblast growth factor Yang WO;Huang YL;Da CD;Cheng JS
  25. Mol Cell Biol. v.16 no.1 Induction of apoptosis by c-Fos protein Preston GA;Lyon TT;Yin Y;Lang JE;Solomon G;Annab L;Srinivasan DG;Alcorta DA;Barrett JC
  26. J Cereb Blood Flow Metab. v.21 no.5 Early c-Fos induction after cerebral ischemia: a possible neuroprotective role Cho S;Park EM;Kim Y;Liu N;Gal J;Volpe BT;Joh TH
  27. Brain Res. v.832 no.1;2 Suppression of post-ischemic-induced fos protein expression by an antisense oligonucleotide to c-fos mRNA leads to increased tissue damage Zhang Y;Widmayer MA;Zhang B;Cui JK;Baskin DS
  28. J Neurosci v.19 no.4 Suppression of postischemic hippocampal nerve growth factor expression by a c-fos antisense oligodeoxynucleotide Cui JK;Hsu CY;Liu PK
  29. Brain Res. v.894 Jun, Fos and Krox in the hippocampus after noxious stimulation: simultaneous-input-dependent expression and nuclear speckling Damien Pearse;Asim Mirza;John Leah
  30. Neuroscience v.93 Hippocampal field CA1 interneuronal nociceptive responses: modulation by medical septal region and morphine Zheng F;Khanna S
  31. Br J Anaesth v.79 no.6 Pharmacodynamics of thiopentone: nocifensive reflex threshold changes correlate with hippocampal electroencephalography Archer DP;Roth SH
  32. Exp Brain Res. v.118 Positron emission tomography reveals changes in global and regional cerebral blood flow during noxious stimulation of normal and inflamed elbow joints in anaesthetized cats Sakiyama Y;Sato A;Senda M;Ishiwata K;Toyama H;Schimidt RF
  33. Proc. Natl. Acad. Sci. USA v.95 New findings of the correlation between acupoints and corresponding brain cortices using functional MRI Cho ZH;Chung SC;Jones JP;Park JB;Park HJ;Lee HJ;Wong EK;Min BI
  34. Jpn. J. Physiol. v.50 Effect of acupuncture-like stimulation on cortical cerebral blood flow in anesthetized rats Uchida, S.;Kagitani, F.;Suzuki, A.;Aikawa, Y.
  35. Acupunct Electrother Res. v.19 no.4 Effects of electro-acupuncture on C-FOS expression in gerbil hippocampus during transient global ischemia. Ying SX;Cheng JS
  36. Acupunct Electrother Res. v.22 no.2 Effects of electroacupuncture on extracellular contents of amino acid neurotransmitters in rat striatum following transient focal cerebral ischemia Zhao P;Cheng J
  37. Zhen Ci Yan Jiu v.21 no.3 Effects of electroacupuncture at du meridian on contents of nitric oxide and endothelin in rats with acute cerebral ischemia Xu N;Xu G;Zhong P;Wang L;Zhu S;Chen Q