The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Juakium-derivative on Experimental Aplastic Anemia

좌귀음가미방이 실험적 재생불량성빈혈에 미치는 영향

  • 박신명 (경희대학교 한의과대학 간계내과학교실) ;
  • 김영철 (경희대학교 한의과대학 간계내과학교실) ;
  • 이장훈 (경희대학교 한의과대학 간계내과학교실) ;
  • 우흥정 (경희대학교 한의과대학 간계내과학교실)
  • Published : 2002.03.01
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Abstract

Objectives : Korean traditional medicinal herbs have been used to improve the function of the hematopoietic system. The purpose of this study is to examine the hematopoietic effects of Juakium-derivative on aplastic anemia. Methods : In vitro, after bone marrow cells of mice with aplastic anemia induced by benzene were cultured with Juakium-derivative, we measured the gene expressions of hematopoietic cytokines, the intracellular TPO and SCF expression and the colony number of CFU-GEMM and BFU-E. Results : The results are summarized as follows : 1. The gene expressions of hematopoietic cytokines (TPO, c-mpl, SCF, c-kit, IL-3, EPO, EpoR, GM-CSF) and the TPO and SCF expression of the group treated with Juakium-derivative increased significantly more than those of the control group. 2. The colony number of CFU-GEMM and BFU-E in the rEPO plus rIL-3 plus Juakium-derivative group increased significantly compared with the only rEPO plus rIL-3 group. Conclusion : It was acknowledged that Juakium-derivative has hemato-potentiating effects on aplastic anemia induced by benzene and it is expected that Juakium-derivative can be used clinically for the patient with hematopoietic system disorder. This study could also be used further as important research data for Korean oriental medicine about hemato-potentiating. The exact mechanism explaining our study would need to be studied further.

Keywords

References

  1. N Engl J Med. v.306 Aplastic anemia Camitta BM;Storb R;Thomas DE
  2. Blood v.75 Epidemiology of aplastic anemia in France: A prospective multicentric study May JY;Baumelou E;Guiguet M
  3. Br J Haematol. v.62 Aplastic anemia in the orient Young NS;Issaragrasil S;Chieh CW;Takaku F
  4. 대한혈액학회지 v.32 no.2 재생불량성빈혈 환자에서 혈청 Stem Cell Factor(SCF)치 및 재조합 인 SCF의 조혈집락세포 성장에 대한 영향 조덕연;김철희;배광봉;김현수;박상준;김종숙;최지영;윤환중;김삼용
  5. 간계내과학 전국한의과대학 간계내과학교수(공저)
  6. Journal of Oriental Medicine v.2 no.1 The Effect of Juakium-derivative on Aplastic Anemia Kim Sun-min;Lee Jang-hoon;Woo Hong-jung
  7. 경희한의대 논문집 v.19 no.2 수 종 한약재가 마우스의 골수 및 비장세포의 조혈촉진과 방사선 방어에 미치는 영향 이능기;최승훈;안규석
  8. 동의병리학회지 v.10 사물탕의 항암제 부작용에 관한 실험적 연구 안희덕
  9. 대전대학교 한의학연구소논문집 v.8 no.1 사물탕과 사물탕 구성약물이 혈구감소증에 미치는 영향에 관한 연구 임석린
  10. Blood v.90 Thrombopoietin is synthesized by bone marrow cells Guerriero A;Worford L;Guo GR;Sheehan K;Waller EK
  11. Am. J. Hematol. v.66 no.3 Oral combination chemotheraphy in conjunction with filgrastim(G-CSF) in the treatment of AIDS-related non-Hodgkin's lymphoma; evaluation of the role of G-CSF ; quality-of-life analysis and long-term follow-up Remick SC;Sedransk N;Haase RF;Blanchard CG;Ramnes CR;Nazeer T;Mastrianni DM;Dezube BJ
  12. Korean J. Immunol. v.21 no.2 Effects of Korean traditional medicine on Murine Hematopoioesis 김승형;임종순
  13. 대한한의학회지 v.22 no.3 수 종의 한약제제가 조혈작용에 미치는 영향 전재현
  14. 경악전서(하) 장개빈
  15. 혈액학 서울대학교 의과대학
  16. 혈액학 권헌영;김영주;노명희;문홍만;송재옹;오현숙;정소웅;조경진
  17. 대한혈액학회지 v.23 no.1 벤젠 대사산물이 마우스 골수 간질세포에 미치는 영향에 관한 실험적 연구 조현찬;김상인
  18. 장부변증논치 김완희;최달영
  19. 장상학 박찬국(편석)
  20. 정교황제내경 홍원식
  21. Annu Rev. Cell Biol. v.3 Growth and differentiation in the hemopoietic system Dexter TM;E Spooncer
  22. Lancet Stem cell migration in developing myeloid and lymphoid stems Moore MA;JT Owen
  23. Blood v.81 Ex vivo expansion of enriched peripheral blood CD34$^+$ progenitor cells factor by stem cell factor, interleukin-1${\beta}$(IL-1${\beta}$), IL-6, IL-3, Interferon-${\gamma}$ and erythropoetin Brugger W;Mocklin W;Heimfeld S;Berenson RJ;Mertelsmann R;Kanz L
  24. Blood v.86 Multi-level effects of fit3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of glanulomonocyte plogenitors/monocytic precursors. Gabbianelli M;Pelosi E;Montesoro E;Valtieri M;Luchetti L;Samoggia P;Vitelli L; Barberi T;Testa U;Lyman S;Peschle C
  25. J. Cell. Physiol. v.131 Recombinant murine granulocyte-macrophage (GM) colony-stimulating factor supports formation of GM and multipotenrial blast cell colonies in culture: comparison with the effects of interleukin-3. Koike K;Ogawa M;Ilhe JN;Miyake T;Shimizu T;Miyajima A;Yokota T;Arai K
  26. J. Exp. Med. v.167 no.6 Proliferation and differentiation of highly enriched mouse hematopoietic stem cells progenitor cells in response to defined growth factors Muller-Sieburg CE;Townsend K;Weissmann IL;Rennick D
  27. Blood v.85 no.7 Thrombo-poietin(c-mpl ligand) acts synergistically with erythropoietin, stem fell factor, and interleukin-11 to enhance murine magakaryocyte colony growth and increases magakaryocyte ploidy in vitro Broudy VC;Lin NL;Kaushansky K
  28. Cell Tissue. Kinet. v.15 no.5 Kinetic analysis of megakarycyte numbers and ploidy levels developing colonies from mouse bone marrow cells Williams N;Jackson H
  29. Blood v.73 no.3 Interacting cytokines regulate in vitro human megakaryocytopoiesis Bruno E;Miller ME;Hoffman R
  30. J. Clin. Invest. v.96 no.3 Thrombopoietin expands erythroid progenitors, increases red cell production and enhances erythroid recovery after myelosuppressive therapy Kaushansky K;Broudy VC;Grossmann A;Humes J;Lin N;Ren HP;Bailey MC
  31. Blood v.82 no.12 Hematopoietic regulators ; redundancy or subtlety? Metcalf D
  32. Annu. Rev. Immunol. v.7 Heterogeneity of mast cells and phenotypic change between subpopulations Kitamura Y
  33. Blood v.81 no.2 Maintenance of high levels of pluripotent hematopoietic stem cells in vitro: effects of stromal cells and c-kit Wineman JP;Nishikawa S;Muller-Sieburg CE
  34. 소아과학회지 v.39 미숙아 빈혈에서 recombinant human erythropoietin의 효과 이영아;김기수;박영서;문형남;홍창의
  35. 대한조혈모세포이식학회지 v.1 조혈모세포 질환에서 동종골수이식후 유전자 재조합형인 과립구-대식세포계 집락성장인자의 효과 최정현;유진홍;박성규;김동욱;이종욱;한치화;민우성;신완식;김춘추;김동집
  36. 古今名方 楊蘊祥
  37. 본초학 전국한의과대학 본초학교실
  38. 대한조혈모세포이식학회지 v.2 냉동 전 및 후에서 제대혈 CD34 양성 조혈모세포의 조혈기능 비교 전진우;홍대식;서원석;김숙자;박성규;원종호;백승호;이권해;박희숙;신상만
  39. Proc. Natl. Acad. Sci. USA v.87 Positive and negative elements regulate human interleukin 3 expression Mathey-Prevot B;Andrews NC;Murphy HS;Kreissman SG;Nathan SG